Does eating yogurt prevent antibioticmassociated diarrhoea? A placebo-controlled randomised controlled trial in general practice
Does eating yogurt prevent antibioticmassociated diarrhoea? A placebo-controlled randomised controlled trial in general practice
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DOI：
10.3399/096016407782604811
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发表时间：
2007-12-01
影响因子：
5.9
通讯作者：
Harvey, Ian
中科院分区：
文献类型：
--
作者：
Conway, Shaun;Hart, Andrew;Harvey, Ian
背景益生菌胶囊已被证明可以减少在许多情况下与腹泻相关的发病率。如果益生菌酸奶同样有效，那么它将提供一种简单且具有成本效益的预防抗生素相关性腹泻的方法。目的研究在口服抗生素的同时食用活性生物酸奶是否可以预防抗生素相关性腹泻。（生物酸奶，商业酸奶，无酸奶）两酸奶组间双盲的随机对照试验。背景：诺福克欣厄姆的单一初级保健全科实践手术。研究人群包括所有年龄段，除了baby.Methodpatients年龄超过1岁，需要1周的抗生素疗程被列入研究。369例患者获得完整随访。干预措施是从服用抗生素的第一天开始，连续12天食用150毫升草莓味酸奶。腹泻被定义为“三个或更多的稀便，每天超过至少连续2天”在12天内开始的antibiotics.ResultsOf的120例患者在无酸奶组，17（14%，95%的置信区间[CI] = 9.0至21.5）腹泻。在118个给予商业酸奶，13（11%，95%CI = 6.6至17.9）开发腹泻; 9的131例患者（7%; 95%CI = 3.7至12.5）给予生物酸奶开发腹泻（P = 0.17）。
BackgroundProbiotic capsules have been shown to reduce the incidence of antibiotic-associated diarrhoea in a number of settings. If probiotic yogurt were equally efficacious then it would provide a simple and cost-effective means of preventing antibiotic-associated diarrhoea.AimTo investigate whether eating live bio yogurt at the time of taking oral antibiotics can prevent antibiotic-associated diarrhoea.Design of studyThis study was a three-arm (bio yogurt, commercial yogurt, no yogurt) randomised controlled trial with double blinding between the two yogurt arms.SettingA single primary care general practice surgery in Hingham, Norfolk. The study population included all ages except babies.MethodPatients aged over 1 year who required a 1-week course of antibiotics were included in the study. There was complete follow up for 369 patients. The intervention was the consumption of 150 ml of live strawberry-flavoured yogurt for 12 days, starting on the first day of taking the antibiotic. Diarrhoea was defined as 'three or more loose stools per day over at least 2 consecutive days' within 12 days of starting the antibiotics.ResultsOf the 120 patients in the no-yogurt group, 17 (14%, 95% confidence interval [CI] = 9.0 to 21.5) developed diarrhoea. Of the 118 given commercial yogurt, 13 (11%, 95% CI = 6.6 to 17.9) developed diarrhoea; nine of the 131 patients (7%; 95% CI = 3.7 to 12.5) given bio yogurt developed diarrhoea (P = 0.17).ConclusionOverall, this study failed to demonstrate that yogurt has any effect on antibiotic-associated diarrhoea.