Contribution of three-dimensional computed tomography in the assessment of fetal skeletal dysplasia
Contribution of three-dimensional computed tomography in the assessment of fetal skeletal dysplasia
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DOI：
10.1002/uog.4001
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发表时间：
2007-05-01
影响因子：
7.1
通讯作者：
Avni, F.
中科院分区：
文献类型：
--
作者：
Cassart, M.;Massez, A.;Avni, F.
目的比较二维超声（2D）和三维CT（3D-CT）对胎儿骨骼异常的诊断价值。10个胎儿在2D超声上出现骨骼异常，1个胎儿超声检查正常，但有石骨症家族史。我们回顾性比较了2D超声和3D-CT与新生儿和/或尸检工作，这是作为金standard.Results 2D超声诊断11例中只有两个提供了正确的诊断。CT在8例中做出了正确的诊断;在其中6例中，2D超声不能确定。3D-CT在显示椎体异常（椎体形状异常、椎弓根间距异常）、骨盆骨畸形（耻骨骨化延迟、髋臼形状异常）和长骨干骺端增大或骨性结合方面比2D超声更准确。3例2D超声和CT均未作出正确诊断。结论在这一系列包括各种骨骼发育不良的病例中，3D-CT的诊断率高于2D超声。这两种成像技术在胎儿发育不良的管理中都是有用的;二维超声是一种有用的筛查测试，三维CT是一种有价值的补充诊断工具。Copyright（c）2007 ISUOG.出版社：John Wiley & Sons，Ltd
Objective To compare the diagnostic accuracy of two-dimensional (2D) ultrasound and three-dimensional (3 D) computed tomography (CT) for the diagnosis of fetal skeletal anomalies.Methods Eleven pregnant women underwent 2D ultrasound and 3D-CT. Ten fetuses presented skeletal anomalies on 2D ultrasound and one fetus had a normal ultrasound exam but a familial history of osteopetrosis. We compared retrospectively the diagnoses established on 2D ultrasound and 3D-CT with the neonatal and/or postmortem work-up, which were used as the gold standard.Results 2D ultrasound provided the correct diagnosis in only two of the 11 cases. CT yielded the correct diagnosis in eight; in six of these, 2D ultrasound bad been inconclusive. 3D-CT was more accurate than was 2D ultrasound in visualizing vertebral anomalies (abnormal shape of the vertebral bodies, abnormal interpedicular distance), pelvic bone malformations (delayed ossification of the pubic bones, abnormal acetabular shape) and enlarged metaphysis or synostoses in long bones. In three cases, neither 2D ultrasound nor CT provided the correct diagnosis.Conclusion In this series, which included a variety of skeletal dysplasias, 3D-CT had a better diagnostic yield than did 2D ultrasound. Both imaging techniques are useful in the management of fetal dysplasia; 2D ultrasound is a useful screening test and 3D-CT is a valuable complementary diagnostic tool. Copyright (c) 2007 ISUOG. Published by John Wiley & Sons, Ltd.