Failure of synbiotic 2000 to prevent postoperative recurrence of Crohn's disease
Failure of synbiotic 2000 to prevent postoperative recurrence of Crohn's disease
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DOI：
10.1007/s10620-006-9549-7
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发表时间：
2007-02-01
影响因子：
3.1
通讯作者：
Eliakim, Rami
中科院分区：
文献类型：
--
作者：
Chermesh, Irit;Tamir, Ada;Eliakim, Rami
克罗恩病 (CD) 的并发症导致约 70-90% 的患者需要进行手术。大多数患者会出现疾病复发的情况。结肠细菌对于 CD 的发生至关重要。因此，尝试通过控制肠道微生物群来预防复发是有道理的。通过益生菌或抗生素治疗是可行的。 Synbiotic 2000 是一款含有 4 种益生菌和 4 种益生元的鸡尾酒。追求它能有效预防术后疾病是合理的。我们试图验证 Synbiotic 2000 天气治疗能否预防 CD 患者术后复发。这是一项前瞻性多中心随机研究。患者以 2:1 的比例随机接受积极治疗或安慰剂。随访包括内窥镜、临床和实验室参数。共招募了 30 名患者。两个治疗组之间在性别、诊断时年龄、手术时年龄、体重、吸烟状况、疾病类型、切除节段长度或手术前治疗方面没有发现差异。每日一次 Synbiotic 2000 或安慰剂治疗的患者之间，未发现内镜或临床复发率存在差异。在我们的小型研究中，Synbiotic 2000 对 CD 患者术后复发没有影响。对接受手术的炎症型克罗恩病患者进行的更大规模研究表明，使用更高剂量的益生菌混合物可能会有效。
Complications of Crohn's disease (CD) lead to surgery in about 70-90% of patients. The majority of patients suffer from relapse of the disease. Colonic bacteria are essential to the development of CD. Therefore, a rationale exists in trying to prevent relapse by manipulation of gut microflora. This is feasible by treatment with probiotics or antibiotics. Synbiotic 2000 is a cocktail containing 4 probiotic species and 4 prebiotics. It is rational to pursue that it could be effective in preventing postoperative disease. We sought to check weather treatment with Synbiotic 2000 could prevent postoperative recurrence in patients with CD. This was a prospective multicenter, randomized study. Patients were randomized to active treatment or placebo in a 2:1 ratio. Follow-up consisted of endoscopic, clinical, and laboratory parameters. Thirty patients were enrolled. No differences were found between the 2 treatment groups regarding gender, age at diagnosis, age at surgery, weight, smoking status, type of disease, length of the resected segment, or medical treatment prior to surgery. No difference in either endoscopic or clinical relapse rate was found between patients treated with once daily dose of Synbiotic 2000 or placebo. In our small study, Synbiotic 2000 had no effect on postoperative recurrence of patients with CD. Larger studies in patients with the inflammatory type of CD undergoing surgery, using higher doses of probiotics cocktail might prove effective.