Autonomous microfluidics with stimuli-responsive hydrogels
Autonomous microfluidics with stimuli-responsive hydrogels
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DOI：
10.1039/b706563a
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发表时间：
2007-01-01
期刊：
影响因子：
3.4
通讯作者：
Jiang, Hongrui
中科院分区：
文献类型：
--
作者：
Dong, Liang;Jiang, Hongrui
由于在单个芯片上执行生物和化学实验室任务具有吸引力，因此对集成微流体系统的兴趣越来越大。构建这些“芯片实验室”的一种直接方法是制造单个组件，并将它们组装成所需的功能。随着微流控系统功能的日益复杂，越来越多的功能组件和相关控制需要集成在一个小型化的芯片上，特别是当需要一个闭环来实现自主功能时。相反，一种新兴的方法是将刺激响应水凝胶直接纳入微流体中，以降低系统的复杂性。由于水凝胶能够将刺激转化为机械动作，以响应其周围的水环境，基于水凝胶的微流体元件可以同时充当传感器和执行器，从而减轻了大多数控制器甚至电源的要求。这为微流体系统提供了自主功能。在本文中，我们将重点介绍一些自主微流控装置，包括阀门、流量分选器、pH调节器、泵、混合器、药物输送装置、流体冷却装置和液体微透镜。
There has been increasing interest in integrated microfluidic systems because performing biological and chemical laboratory tasks on a single chip is appealing. One straightforward approach to constructing these 'lab on chips' is to fabricate individual components and to assemble them for desired functionalities. As the functionalities of the microfluidic systems become increasingly complicated, more functional components and relevant controls need to be integrated on a miniaturized chip, especially when a closed loop is needed for autonomous functionality. Instead, an emerging approach is to incorporate stimuli-responsive hydrogels directly into microfluidics to reduce the system complexity. Due to the hydrogels' ability of transducing stimuli into mechanical actions in response to their surrounding aqueous environment, hydrogel-based microfluidic elements can act as both sensors and actuators simultaneously, alleviating the requirement of most controls and even power sources. This provides microfluidic systems with autonomous functionalities. In this article, we will focus on a few autonomous microfluidic devices including valves, flow sorters, pH regulators, pumps, mixers, drug-delivery devices, fluidic cooling devices, and liquid microlenses.