Factors influencing the expression of dental extracellular matrix biomineralization.

Factors influencing the expression of dental extracellular matrix biomineralization.
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影响牙细胞外基质生物矿化表达的因素。

DOI:
10.1002/9780470513637.ch3
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发表时间:
1988
期刊:
Ciba Foundation symposium
影响因子:
--
通讯作者:
Evans,J
Evans,J
中科院分区:
--
文献类型:
--
作者:
Slavkin,HC;Snead,ML;Zeichner-David,M;MacDougall,M;Fincham,A;Lau,EC;Luo,W;Nakamura,M;Oliver,P;Evans,J

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牙齿器官的形成为研究细胞介导的细胞外基质(ECM)生物矿化的细胞和分子生物学提供了许多机会。通过确定细胞粘附分子(CAMS)、底物粘附分子(SAMs)、牙本质光蛋白和牙釉质基因产物在顺序发育阶段的表达时间和地点,研究了与牙齿形成相关的调节过程。在无血清、化学定义的培养基中进行的体外器官型培养研究表明,形态发生和细胞分化都需要指导性和许可性信号传导。内在发育指令(自分泌因子和旁分泌因子)独立于长期激素或外源性生长因子起作用,并介导牙板起始到牙冠发育阶段的形态发生。本文综述了实验胚胎学、重组DNA技术和免疫细胞学的研究结果,以阐明与成釉细胞分化、成牙本质分化和牙釉质ECM生物矿化相关的指导性上皮-间充质相互作用的响应机制。
The forming tooth organ provides a number of opportunities to investigate the cellular and molecular biology of cell‐mediated extracellular matrix (ECM) biomineralization. Regulatory processes associated with tooth formation are being investigated by identifying when and where cell adhesion molecules (CAMS), substrate adhesion molecules (SAMs), dentine phos‐phoprotein and enamel gene products are expressed during sequential developmental stages. In vitro organotypic culture studies in serumless, chemically‐defined medium, have shown that instructive and permissive signalling are required for both morphogenesis and cytodifferentiation. Intrinsic developmental instructions (autocrine and paracrine factors) act independently of long‐range hormonal or exogenous growth factors and mediate morphogenesis from the initiation of the dental lamina to the crown stages of tooth development. This review summarizes the results of studies using experimental embryology, recombinant DNA technology and immunocytology to elucidate mechanisms responsive to instructive epithelial‐mesenchymal interactions associated with ameloblast differentiation, odontoblast differentiation, and dentine and enamel ECM biomineralization.
成牙本质细胞分化和成牙本质细胞层的形成。
DOI: --
发表时间: 1985
期刊: Journal of dentistry research
影响因子: --
作者:
J. Ruch
通讯作者: J. Ruch
表皮生长因子抑制培养的小鼠胚胎牙齿的形态发生和细胞分化。
DOI: --
发表时间: 1985
影响因子: 2.7
作者:
A. Partanen;P. Ekblom;I. Thesleff
通讯作者: I. Thesleff
DOI: --
发表时间: 1982
影响因子: 2.7
作者:
M. Olivé;J. Ruch
通讯作者: J. Ruch
DOI: --
发表时间: 1983
影响因子: 4.1
作者:
A. Fincham;A. Belcourt;J. Termine;W. Butler;W. C. Cothran
通讯作者: W. C. Cothran
DOI: --
发表时间: 1985
影响因子: 4.1
作者:
M. Macdougall;M. Zeichner‐David;H. Slavkin
通讯作者: H. Slavkin