Dopaminergic modulation of basal ganglia output through coupled excitation-inhibition
Dopaminergic modulation of basal ganglia output through coupled excitation-inhibition
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DOI：
10.1073/pnas.1611146114
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发表时间：
2017-05-30
影响因子：
11.1
通讯作者：
Perkel, David J.
中科院分区：
文献类型：
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作者：
Budzillo, Agata;Duffy, Alison;Perkel, David J.
学习和保持熟练的动作需要探索运动空间和选择适当的动作。鸣禽的发声学习和社会环境依赖的可塑性依赖于基底神经节回路，它积极地产生发声的变化。基底神经节中的多巴胺减少了鸟儿在求偶时的神经变异。在这里，我们提出了一个独特的证据，紧张性活跃，兴奋性中间神经元在鸣禽基底神经节，使强大的突触连接到输出苍白球神经元，往往与抑制事件的时间。多巴胺受体活性调节这些兴奋性和抑制性事件在体外的耦合，这导致在一个动态的变化，在一个模拟的人口接受兴奋性和抑制性输入的基底神经节输出神经元的同步性。因此，兴奋性中间神经元作为一种生物物理机制，用于在该回路中引入或调节神经变异性。
Learning and maintenance of skilled movements require exploration of motor space and selection of appropriate actions. Vocal learning and social context-dependent plasticity in songbirds depend on a basal ganglia circuit, which actively generates vocal variability. Dopamine in the basal ganglia reduces trial-to-trial neural variability when the bird engages in courtship song. Here, we present evidence for a unique, tonically active, excitatory interneuron in the songbird basal ganglia that makes strong synaptic connections onto output pallidal neurons, often linked in time with inhibitory events. Dopamine receptor activity modulates the coupling of these excitatory and inhibitory events in vitro, which results in a dynamic change in the synchrony of a modeled population of basal ganglia output neurons receiving excitatory and inhibitory inputs. The excitatory interneuron thus serves as one biophysical mechanism for the introduction or modulation of neural variability in this circuit.