Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence.
Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence.
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DOI：
10.1001/jama.1992.03480130122036
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发表时间：
1992-04
期刊：
影响因子：
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通讯作者：
L. Lipsitz;A. Goldberger
中科院分区：
文献类型：
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作者：
L. Lipsitz;A. Goldberger
“复杂性”的概念源自非线性动力学领域，可用于测量产生类似于“混沌”的高度可变波动的生理过程的输出。我们回顾了表明生理衰老与健康器官系统功能动态复杂性普遍丧失相关的数据，并假设这种复杂性丧失导致适应生理压力的能力受损。这一假设得到了观察结果的支持，这些观察结果显示，多种生理过程中复杂变异性的丧失与年龄相关，包括心血管控制、脉动激素释放和脑电图电位。如果进一步的研究支持这一假设，基于混沌理论和分形相关几何概念的复杂性测量可能会提供新的方法来监测衰老并测试特定干预措施的有效性，以改变与年龄相关的适应能力下降。
The concept of "complexity," derived from the field of nonlinear dynamics, can be adapted to measure the output of physiologic processes that generate highly variable fluctuations resembling "chaos." We review data suggesting that physiologic aging is associated with a generalized loss of such complexity in the dynamics of healthy organ system function and hypothesize that such loss of complexity leads to an impaired ability to adapt to physiologic stress. This hypothesis is supported by observations showing an age-related loss of complex variability in multiple physiologic processes including cardiovascular control, pulsatile hormone release, and electroencephalographic potentials. If further research supports this hypothesis, measures of complexity based on chaos theory and the related geometric concept of fractals may provide new ways to monitor senescence and test the efficacy of specific interventions to modify the age-related decline in adaptive capacity.