Intra-erythrocyte deposition of growth hormone in rheumatic diseases
Intra-erythrocyte deposition of growth hormone in rheumatic diseases
复制标题
DOI：
10.1007/s00296-002-0245-4
复制
发表时间：
2003-01-01
影响因子：
4
通讯作者：
Malemud, CJ
中科院分区：
文献类型：
--
作者：
Denko, CW;Boja, B;Malemud, CJ
采用标准放射免疫测定法对骨关节炎、弥漫性特发性骨骼肥厚 (DISH)、痛风和干燥综合征患者以及一组正常志愿者（对照组）的匹配基础红细胞内生长激素 (GH) 和血清 GH 水平进行定量。骨关节炎和 DISH 患者血液样本中的基础红细胞内 GH 浓度显着高于血清 GH 浓度 (P < 0.05)，但痛风或干燥综合征患者的血液样本中则不然。回归分析确定基础血清 GH 水平与年龄无关。虽然骨关节炎和 DISH 中红细胞内 GH 水平超过了血清 GH 水平，但红细胞内 GH 并不是骨关节炎、DISH 或对照组血清 GH 水平的强有力预测因子。
Standard radioimmunoassay was employed to quantify matched basal intra-erythrocyte growth hormone (GH) and serum GH levels from patients with osteoarthritis, diffuse idiopathic skeletal hyperostosis (DISH), gout, and Sjogren's syndrome and in a group of normal volunteers (control group). Basal intra-erythrocyte GH concentration was significantly higher (P < 0.05) than serum GH concentration in blood samples from patients with osteoarthritis and DISH but not from those with gout or Sjogren's syndrome. Regression analysis determined that basal serum GH levels did not correlate with age. While intra-erythrocyte GH levels exceeded serum GH levels in osteoarthritis and DISH, intra-erythrocyte GH was not a strong predictor of serum GH levels in osteoarthritis, DISH, or in the control group.