An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers
An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers
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西替利嗪对健康志愿者认知功能和精神运动表现影响的研究
DOI：
10.1007/s002280000257
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发表时间：
2001
影响因子：
2.9
通讯作者：
I. Hindmarch
中科院分区：
文献类型：
--
作者：
Z. Shamsi;S. Kimber;I. Hindmarch
目的：采用随机双盲交叉试验，比较第二代H1受体拮抗剂西替利嗪2.5、5、10 mg与氯雷他定10、20、40 mg、异丙嗪25 mg及安慰剂对健康志愿者认知功能和精神运动的影响。方法：受试者分别于服药后1.5、3、6 h进行认知功能和精神运动功能测试。测试组合包括临界闪烁融合(CFF)、选择反应时间(CRT)、补偿跟踪任务(CTT)和主观镇静评估(LARS)。结果：西替利嗪和氯雷他定在所有测试剂量下与安慰剂均无显著差异。然而，正如预期的那样，除CTT外，所有措施都被异丙嗪显著干扰(P<；0.05)。异丙嗪使所有测试点的CFF阈值降低；这些差异在给药后3h和6h有显著差异(P<；0.05)。在给药后3h，总反应时间也显著增加。在服用异丙嗪后，所有时间点的主观镇静报告都显著增加(P<；0.05)。结论：这些结果允许得出结论，在一项研究中，推荐的治疗剂量10 mg的西替利嗪对精神运动和认知功能的某些方面没有干扰影响，其中心理测量评估被证明对损害敏感，阳性对照异丙嗪25 mg的效果证明了这一点。
Objective:The cognitive and psychomotor effects of 2.5, 5 and 10 mg cetirizine, a second-generation H1receptor antagonist, were compared with loratadine 10, 20 and 40 mg, promethazine 25 mg and placebo in 24 healthy volunteers in a double-blind, randomised cross-over study.Methods:Following each dose, subjects were required to perform a series of tests of cognitive function and psychomotor performance at 1.5, 3 and 6 h post-dose. The test battery consisted of critical flicker fusion (CFF), choice reaction time (CRT), compensatory tracking task (CTT) and assessment of subjective sedation (LARS).Results:Cetirizine and loratadine at all doses tested were not significantly different from placebo in any of the tests used. However, as expected for a verum, all measures with the exception of CTT were significantly disrupted by promethazine (P<0.05). Promethazine caused a reduction in CFF threshold at all test points; these differences were significant at 3 h and 6 h post-dose (P<0.05). There was also a significant increase in total reaction time at 3 h post-promethazine administration. Subjective reports of sedation were significantly greater following the administration of promethazine at all time points (P<0.05).Conclusions:These results allow the conclusion that cetirizine at its recommended therapeutic dose of 10 mg is demonstrably free from disruptive effects on aspects of psychomotor and cognitive function in a study where the psychometric assessments have been shown to be sensitive to impairment, as evidenced by the effects of the positive control, promethazine 25 mg.