Multiparametric mapping of white matter microstructure in catatonia
Multiparametric mapping of white matter microstructure in catatonia
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DOI：
10.1038/s41386-020-0691-2
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发表时间：
2020-05-05
影响因子：
7.6
通讯作者：
Hirjak, Dusan
中科院分区：
文献类型：
--
作者：
Wasserthal, Jakob;Maier-Hein, Klaus H.;Hirjak, Dusan
紧张症的特征是运动、情感和行为异常。迄今为止，白色物质（WM）异常在精神分裂症谱系障碍（SSD）伴紧张症患者中的具体作用在很大程度上是未知的。在这项研究中，扩散磁共振成像（dMRI）数据收集了111右撇子SSD患者和28名健康对照。采用Northoff紧张症评定量表（NCRS）检查紧张症症状。我们使用全脑基于束的空间统计学（TBSS），tractometry（沿着束统计使用TractSeg）和图形分析（聚类系数-CCO，局部介数中心-BC），以提供一个特定的WM微结构异常的基础紧张症在SSD的框架。采用分类方法后，事后分析显示，通过胼胝体、皮质脊髓束和丘脑运动前束的纤维束测量法测量的各向异性分数（FA）存在差异，以及通过右侧上级顶叶皮质（SPC）和左侧尾状核的图形分析得出的CCO增加（NCRS总评分>= 3; n = 30）与非紧张性患者（NCRS总评分= 0; n = 29）相比。根据DSM-IV-TR（n = 43），在紧张症患者中，紧张症症状与左侧皮质脊髓束的FA变异（tractometry）和左侧眶额皮质、初级运动皮质、辅助运动区和壳核的CCO相关。这项研究支持的概念，连接眶额/顶叶，丘脑和纹状体区的WM束结构重组有助于紧张症的SSD患者。
Catatonia is characterized by motor, affective and behavioral abnormalities. To date, the specific role of white matter (WM) abnormalities in schizophrenia spectrum disorders (SSD) patients with catatonia is largely unknown. In this study, diffusion magnetic resonance imaging (dMRI) data were collected from 111 right-handed SSD patients and 28 healthy controls. Catatonic symptoms were examined on the Northoff Catatonia Rating Scale (NCRS). We used whole-brain tract-based spatial statistics (TBSS), tractometry (along tract statistics using TractSeg) and graph analytics (clustering coefficient-CCO, local betweenness centrality-BC) to provide a framework of specific WM microstructural abnormalities underlying catatonia in SSD. Following a categorical approach, post hoc analyses showed differences in fractional anisotrophy (FA) measured via tractometry in the corpus callosum, corticospinal tract and thalamo-premotor tract as well as increased CCO as derived by graph analytics of the right superior parietal cortex (SPC) and left caudate nucleus in catatonic patients (NCRS total score >= 3; n = 30) when compared to non-catatonic patients (NCRS total score = 0; n = 29). In catatonic patients according to DSM-IV-TR (n = 43), catatonic symptoms were associated with FA variations (tractometry) of the left corticospinal tract and CCO of the left orbitofrontal cortex, primary motor cortex, supplementary motor area and putamen. This study supports the notion that structural reorganization of WM bundles connecting orbitofrontal/parietal, thalamic and striatal regions contribute to catatonia in SSD patients.