Protein Disulfide Isomerases Function as the Missing Link Between Diabetes and Cancer.
Protein Disulfide Isomerases Function as the Missing Link Between Diabetes and Cancer.
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蛋白质二硫键异构酶是糖尿病和癌症之间缺失的一环。
DOI：
10.1089/ars.2022.0098
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发表时间：
2022
影响因子：
6.6
通讯作者：
Wei,Qiou
中科院分区：
文献类型：
--
作者：
Jiang,Hong;Thapa,Pratik;Hao,Yanning;Ding,Na;Alshahrani,Aziza;Wei,Qiou
意义：糖尿病长期以来被认为是癌症的独立危险因素，但对将两种疾病联系在一起的生物介质的机制了解不足。了解糖尿病和癌症之间的致病关联已成为许多研究的重点，研究结果是潜在的有价值的发展有效的预防或治疗策略为both disorders.Recent Advances：文献摘要揭示了糖尿病和癌症之间的可能联系，通过蛋白质二硫键异构酶（PDI）的家庭。历史以及最近的研究结果的结构，生物化学和生物学的PDI家族进行了总结在this review.Critical Issues：PDI在一般功能的氧化还原酶和蛋白伴侣蛋白质的质量控制，纠正或以其他方式消除错误折叠的蛋白质在氧化应激和内质网应激的条件下，分别。然而，PDI家族的个体成员可能对糖尿病和癌症的发病机制有独特的贡献。本文综述了蛋白质二硫键异构酶相关蛋白（PDIA）1、PDIA 6和PDIA 15等典型成员在糖尿病和癌症发病机制中的作用，以及它们如何通过信号通路的相互作用成为两种疾病的潜在联系。未来方向：PDIs的普遍存在为科学界开发同时治疗糖尿病和癌症的靶向药物带来了困难和挑战。了解个体PDI在特定疾病背景下的分子贡献可能为基于机制的靶向治疗的发展提供一些见解。抗氧化剂。Redox Signal.37，1191-1205.
Significance:Diabetes has long been recognized as an independent risk factor for cancer, but there is insufficient mechanistic understanding of biological mediators that bridge two disorders together. Understanding the pathogenic association between diabetes and cancer has become the focus of many studies, and findings are potentially valuable for the development of effective preventive or therapeutic strategies for both disorders.Recent Advances:A summary of literature reveals a possible connection between diabetes and cancer through the family of protein disulfide isomerase (PDI). Historical as well as the most recent findings on the structure, biochemistry, and biology of the PDI family were summarized in this review.Critical Issues:PDIs in general function as redox enzymes and protein chaperones to control the quality of proteins by correcting or otherwise eliminating misfolded proteins in conditions of oxidative stress and endoplasmic reticulum stress, respectively. However, individual members of the PDI family may contribute uniquely to the pathogenesis of diabetes and cancer. Studies of exemplary members such as protein disulfide isomerase-associated (PDIA) 1, PDIA6, and PDIA15 were reviewed to highlight their contributions in the pathogenesis of diabetes and cancer and how they can be potential links bridging the two disorders through the cross talk of signaling pathways.Future Directions:Apparently ubiquitous presence of the PDIs creates difficulties and challenges for scientific community to develop targeted therapeutics for the treatment of diabetes and cancer simultaneously. Understanding molecular contribution of individual PDI in the context of specific disease may provide some insights into the development of mechanism-based target-directed therapeutics.Antioxid. Redox Signal.37, 1191–1205.