Origin of vertebrate limb muscle: the role of progenitor and myoblast populations.
Origin of vertebrate limb muscle: the role of progenitor and myoblast populations.
复制标题
脊椎动物肢体肌肉的起源：祖细胞和肌细胞种群的作用。
DOI：
10.1016/b978-0-12-385940-2.00001-2
复制
发表时间：
2011
影响因子：
--
通讯作者：
Kardon G
中科院分区：
文献类型：
--
作者：
Murphy M;Kardon G
肌肉的发育、生长和再生贯穿于脊椎动物的一生。在羊膜中，肌发生发生在四个连续的，虽然重叠，但在时间上不同的阶段。了解胚胎、胎儿、新生儿和成人肌肉是如何由肌肉祖细胞和成肌细胞形成的是一个活跃的研究领域。在这篇综述中，我们研究了最近在小鼠中进行的表达、基因功能丧失和遗传谱系研究，特别关注肢体肌肉发生。我们综合这些研究，提出一个当前的模型，如何胚胎，胎儿，新生儿和成人肌肉是如何形成的肢体。
Muscle development, growth, and regeneration takes place throughout vertebrate life. In amniotes myogenesis takes place in four successive, temporally distinct, although overlapping phases. Understanding how embryonic, fetal, neonatal, and adult muscle are formed from muscle progenitors and committed myoblasts is an area of active research. In this review we examine recent expression, genetic loss-of-function, and genetic lineage studies that have been conducted in the mouse, with a particular focus on limb myogenesis. We synthesize these studies to present a current model of how embryonic, fetal, neonatal, and adult muscle are formed in the limb.