Function of steroidogenic factor 1 during development and differentiation of the reproductive system.
Function of steroidogenic factor 1 during development and differentiation of the reproductive system.
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DOI：
10.1530/ror.0.0050136
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发表时间：
2000-09
期刊：
影响因子：
--
通讯作者：
Y. Sadovsky;C. Dorn
中科院分区：
文献类型：
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作者：
Y. Sadovsky;C. Dorn
完整的生殖发育取决于类固醇和其他内分泌信号。虽然最近的发现已经阐明了性别分化的重要步骤，但调节类固醇产生组织发育的复杂机制仍然难以捉摸。在成年人中，复杂的反馈机制决定了下丘脑和垂体对类固醇激素生物合成的调节。类固醇生成因子1（SF-1）是核受体蛋白超家族的孤儿成员，在内分泌和生殖系统的发育和分化中起着关键作用。本文综述了SF-1的功能，其作用机制，以及SF-1与性别分化的其他决定因素的相互作用的观点。而SF-1是许多类固醇生成酶的表达所必需的，它的存在可能与类固醇生成功能无关。此外，不同的共调节因子调节SF-1对基因转录的影响。这些相互作用的意义进行了讨论的背景下，生殖发育和功能。其他孤儿或配体依赖性核蛋白可能具有类似的机制。
Intact reproductive development depends on steroids and other endocrine signals. Although recent discoveries have elucidated important steps of sexual differentiation, the intricate mechanisms that regulate the development of steroid-producing tissues remain elusive. In adults, complex feedback mechanisms determine the hypothalamic and pituitary regulation of steroid hormone biosynthesis. Steroidogenic factor 1 (SF-1), an orphan member of the nuclear receptor superfamily of proteins, plays a critical role in development and differentiation of the endocrine and reproductive systems. This review provides an overview of the function of SF-1, its mechanism of action, and a perspective on the interaction of SF-1 with other determinants of sexual differentiation. Whereas SF-1 is essential for the expression of numerous steroidogenic enzymes, its presence may not correlate with steroidogenic function. Moreover, diverse co-regulators modulate the influence of SF-1 on gene transcription. The significance of these interactions is discussed in the context of reproductive development and function. Other orphan or ligand-dependent nuclear proteins may share similar mechanisms.