Sex differences in the regulation of body weight.
Sex differences in the regulation of body weight.
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DOI：
10.1016/j.physbeh.2009.02.017
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发表时间：
2009-05-25
影响因子：
2.9
通讯作者：
Clegg DJ
中科院分区：
文献类型：
--
作者：
Shi H;Clegg DJ
肥胖症及其相关的健康障碍和费用正在增加。男性和女性在身体脂肪储存的方式和位置，他们分泌的激素与脂肪的比例以及他们的大脑对调节身体脂肪的信号的反应方式方面存在差异。腹内脂肪库中的脂肪积累与发展心血管问题、2型糖尿病、某些癌症和其他疾病的风险相关。男性和绝经后女性在腹腔内脂肪库中积累的脂肪比绝经前女性多，因此发生与肥胖相关的代谢并发症的风险更大。这篇综述的目的是探讨我们所知道的关于脂肪组织积累和沉积的性二态性。由于肥胖症和代谢综合征的流行以及绝经后这些疾病的倾向性迅速增加，阐明性激素可能调节脂肪积累和储存方式的机制是研究的一个关键领域。
Obesity and its associated health disorders and costs are increasing. Males and females differ in terms of how and where body fat is stored, the hormones they secrete in proportion to their fat, and the way their brains respond to signals that regulate body fat. Fat accumulation in the intra-abdominal adipose depot is associated with the risk for developing cardiovascular problems, type-2 diabetes mellitus, certain cancers and other disorders. Men and postmenopausal women accumulate more fat in the intra-abdominal depot than do premenopausal women, and therefore have a greater risk of developing metabolic complications associated with obesity. The goal of this review is to explore what we know about sexual dimorphisms in adipose tissue accrual and deposition. Elucidating the mechanisms by which sex hormones may modulate the way in which fat is accumulated and stored is a critical area of research due to the prevalence of obesity and the metabolic syndrome, and the rapid increase in propensity for these diseases following menopause.