Low RPS14 expression in MDS without 5q ‐ aberration confers higher apoptosis rate of nucleated erythrocytes and predicts prolonged survival and possible response to lenalidomide in lower risk non‐5q‐ patients
Low RPS14 expression in MDS without 5q ‐ aberration confers higher apoptosis rate of nucleated erythrocytes and predicts prolonged survival and possible response to lenalidomide in lower risk non‐5q‐ patients
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DOI：
10.1111/ejh.12105
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发表时间：
2013-06
影响因子：
3.1
通讯作者：
Lingyun Wu;Xiao Li;F. Xu;Zheng Zhang;Chun-kang Chang;Q. He
中科院分区：
文献类型：
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作者：
Lingyun Wu;Xiao Li;F. Xu;Zheng Zhang;Chun-kang Chang;Q. He
核糖体蛋白S14（RPS14）的单倍不足已被确定为具有孤立del（5q）的骨髓增生异常综合征（MDS）的致病因素。本研究旨在研究RPS14在无5q缺失的MDS中的表达，以及低表达的RPS14在非5q MDS的发病机制和预后以及来那度胺反应预测中的作用。
Haploinsufficiency of the ribosomal protein S14 (RPS14) has been identified as a causal factor in myelodysplastic syndrome (MDS) with isolated del (5q). This study was carried out to investigate RPS14 expression in MDS without 5q deletion and the role of lower expressed RPS14 plays in pathogenesis and the prognosis and lenalidomide‐response predicting of non‐5q‐MDS.