Influence of Age and Other Factors on Cytokine Expression Profiles in Healthy Children - A Systematic Review
Influence of Age and Other Factors on Cytokine Expression Profiles in Healthy Children - A Systematic Review
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DOI：
10.3389/fped.2017.00255
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发表时间：
2017-12-14
影响因子：
2.6
通讯作者：
Ritz, Nicole
中科院分区：
文献类型：
--
作者：
Decker, Marie-Luise;Grobusch, Martin P.;Ritz, Nicole
近年来，细胞因子作为传染病和炎症性疾病的诊断生物标志物而备受关注。然而，对成熟和正常年龄相关值的理解是有限的。本综述总结了年龄和其他因素对健康儿童可溶性细胞因子和细胞内细胞因子表达谱影响的证据。 IFN-γ、IL-6、IL-10 和 TNF-α 是最常研究的细胞因子，其中 IFN-γ 和 TNF-α 一致显示与年龄相关的细胞因子增加。在资源有限的环境中，IL-13 会出现与年龄相关的下降。对于其他细胞因子，包括 IL-1RA、IL-2 和 IL-10，已经描述了单峰或双峰曲线，并且结果受到研究背景的影响。总之，尽管目前对细胞因子表达发展的了解有限，但年龄明显影响健康儿童的表达谱。当在诊断测定中测量细胞因子表达或作为生物标志物时，需要考虑儿童时期细胞因子表达的动态。此外，细胞因子靶向药物在儿童中使用时可能需要调整至正常值。
Cytokines have attracted much attention as diagnostic biomarkers for infectious and inflammatory diseases in recent years. However, understanding of maturation and normal age-associated values is limited. This review summarizes evidence on the influence of age and other factors on expression profiles of soluble and intracellular cytokines in healthy children. IFN-gamma, IL-6, IL-10, and TNF-alpha are the most frequently investigated cytokines, of which an age-associated increase was shown consistently for IFN-gamma and TNF-alpha. An age-associated decrease of IL-13 was seen in resource-limited settings. For other cytokines, including IL-1RA, IL-2, and IL-10, uni-or bimodal curves have been described, and results were influenced by study setting. To conclude, despite limited current understanding of the development of cytokine expression, age clearly influences expression profiles in healthy children. Dynamics of cytokine expression in childhood need to be considered when these are measured in diagnostic assays or as biomarkers. In addition, cytokine-targeting agents may require adjustment for normal values when used in children.