GPR12 Selections of the metabolites from an endophytic Streptomyces sp Asociated with Cistanches deserticola
GPR12 Selections of the metabolites from an endophytic Streptomyces sp Asociated with Cistanches deserticola
复制标题
DOI：
10.1007/s12272-001-1276-4
复制
发表时间：
2008-09-01
影响因子：
6.7
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Lin, Zhen-Jian;Lu, Xiao-Ming;Zhu, Weiming
从肉苁蓉（Cistanches deserticola Y.）C.妈...对AC-2的发酵液进行化学分析，得到15个化合物，包括K1115 A（1）、酪醇（2）、苯乙胺衍生物（3，4）、环二肽（5-8）、核苷及其苷元（9-13）、N-乙酰色胺（14）和吡咯-2-羧酸（15）。在转染GPR 12的CHO和HEK 293细胞中，只有酪醇能促进细胞内cAMP的增加，这意味着酪醇可能是GPR 12的一种可能的配体。
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y. C. Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.