Biomiarkers, Early Diagnosis, and Clinical Predictors of Bronchopulmonary Dysplasia
Biomiarkers, Early Diagnosis, and Clinical Predictors of Bronchopulmonary Dysplasia
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DOI：
10.1016/j.clp.2015.08.004
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发表时间：
2015-12-01
影响因子：
2.1
通讯作者：
Ambalavanan, Namasivayam
中科院分区：
文献类型：
--
作者：
Lal, Charitharth Vivek;Ambalavanan, Namasivayam
支气管肺发育不良（BPD）的发病机制是多因素的，BPD的临床表型非常多变。已经提出了几种临床和实验室生物标志物，用于早期识别BPD风险较高的婴儿，并用于确定诊断为BPD的婴儿的预后。作者回顾了关于BPD预测工具和生物标志物的现有文献，使用基于成像、肺功能测量和不同体液中各种分析物测量的临床变量和生物标志物，这些分析物已被确定为以靶向方式或通过无偏倚的组学分析与BPD相关。
The pathogenesis of bronchopulmonary dysplasia (BPD) is multifactorial, and the clinical phenotype of BPD is extremely variable. Several clinical and laboratory biomarkers have been proposed for the early identification of infants at higher risk of BPD and for determination of prognosis of infants with a diagnosis of BPD. The authors review available literature on prediction tools and biomarkers of BPD, using clinical variables and biomarkers based on imaging, lung function measures, and measurements of various analytes in different body fluids that have been determined to be associated with BPD either in a targeted manner or by unbiased omic profiling.