Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism.
Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism.
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甲状腺功能正常且轻度亚临床甲减的绝经后妇女更年期激素治疗的临床观察
DOI：
10.1186/s12902-023-01269-7
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发表时间：
2023-01-23
影响因子：
2.7
通讯作者：
Zhou, Jianhong
中科院分区：
文献类型：
--
作者：
Xu, Wenxian;Huang, Yizhou;Ma, Linjuan;Chen, Peiqiong;Li, Saisai;Chu, Ketan;Lan, Yibing;Li, Chunming;Song, Yang;Ying, Qian;Zhou, Jianhong
关键词：
探讨绝经后甲状腺功能正常和轻度亚临床甲减妇女经绝经期激素治疗后内分泌激素及代谢指标的变化。对587例接受MHT的绝经后妇女进行了回顾性研究。中位（第25- 75百分位数）年龄为52（49-54）岁。根据初诊时促甲状腺激素（TSH）水平将患者分为3组：I组（正常甲状腺功能但TSH正常范围偏低，n = 460）、II组（正常甲状腺功能但TSH正常范围偏高，n = 106）和III组（轻度亚临床甲减，n = 21）。在连续口服MHT方案使用相同的雌二醇效力6-18个月周期后，重新评估血清内分泌激素和代谢指标。与基线相比，I组和II组的血清TSH水平显著变化，但所有值均在正常范围内。第III组血清TSH水平无显著差异。治疗后，所有血清游离三碘甲状腺原氨酸和游离甲状腺素水平均在正常范围内。I组血清总胆固醇、甘油三酯、空腹血糖、空腹胰岛素水平及稳态模型评估的胰岛素抵抗指数均显著降低。治疗前和治疗后，组III中所有观察到的血脂和血糖参数均无显著差异。MHT不影响甲状腺功能正常和轻度亚临床甲状腺功能减退的绝经后妇女的甲状腺功能。MHT可改善TSH正常范围较低的甲状腺功能正常妇女的血脂和血糖指标。
To evaluate the endocrine hormone and metabolic indices in postmenopausal women with euthyroid and mild subclinical hypothyroidism after menopause hormone therapy (MHT). A retrospective study of 587 postmenopausal women receiving MHT was conducted. Median (25–75th percentile) age was 52 (49–54) years. According to thyroid stimulating hormone (TSH) levels at initial diagnosis, the patients were divided into three groups: I (euthyroid with low normal TSH range, n = 460), II (euthyroid with upper normal TSH range, n = 106) and III (mild subclinical hypothyroidism, n = 21). After a continuous oral MHT regimen using the same estradiol potency for 6–18 month cycles, serum endocrine hormone and metabolic indices were reassessed. Compared with baseline, serum TSH levels in groups I and II significantly changed but all values were within the normal range. No significant difference was observed in serum TSH levels in group III. After treatment, all serum free tri-iodothyronine and free thyroxine levels were within the normal range. Serum total cholesterol, triglyceride, fasting plasma glucose, fasting insulin levels and homeostasis model assessment of insulin resistance index had significantly decreased in group I. There were no significant differences in all observed lipid and glucose parameters in group III, before and after treatment. MHT did not affect thyroid function in postmenopausal women with euthyroid and mild subclinical hypothyroidism. MHT led to an improvement in lipid and glucose indicators in euthyroid women with low normal TSH range.
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影响因子：
5.8
作者：
AIN, KB;MORI, Y;REFETOFF, S
通讯作者：
REFETOFF, S
影响因子：
5.8
作者：
Wartofsky, L;Dickey, RA
通讯作者：
Dickey, RA
DOI：
10.1016/s1071-5576(00)00049-6
发表时间：
2000-05-01
期刊：
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
影响因子：
--
作者：
Bhavnani, BR;Nisker, JA;Milne, JK
通讯作者：
Milne, JK
影响因子：
8.2
作者：
Margolis, KL;Bonds, DE;Howard, BV
通讯作者：
Howard, BV
影响因子：
2.8
作者：
del Ghianda, S.;Tonacchera, M.;Vitti, P.
通讯作者：
Vitti, P.