Exosome-based immunotherapy
Exosome-based immunotherapy
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DOI：
10.1007/s00262-003-0472-x
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发表时间：
2004-03-01
影响因子：
5.8
通讯作者：
Zitvogel, L
中科院分区：
文献类型：
--
作者：
Chaput, N;Taïeb, J;Zitvogel, L
外泌体是起源于晚期内体并由培养物中的造血细胞和上皮细胞分泌的小膜囊泡。外泌体的蛋白质和脂质组成是独特的，可能会揭示一些外泌体的生物发生和功能。从专职抗原呈递细胞分泌的外来体（即，B淋巴细胞和树突状细胞）富含MHC I类和II类复合物、共刺激分子和hsp 70 -90分子伴侣，因此已经对其在体外和体内的免疫调节能力进行了更广泛的研究。本文将介绍与肿瘤或DC衍生的外泌体有关的主要生物学特征，强调其免疫刺激功能，并讨论其在癌症免疫治疗中的应用。
Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are enriched in MHC class I and II complexes, costimulatory molecules, and hsp70-90 chaperones, and have therefore been more extensively studied for their immunomodulatory capacities in vitro and in vivo. This review will present the main biological features pertaining to tumor or DC-derived exosomes, will emphasize their immunostimulatory function, and will discuss their implementation in cancer immunotherapy.