Stress and psychophysiological dysregulation in patients with Fibromyalgia syndrome
Stress and psychophysiological dysregulation in patients with Fibromyalgia syndrome
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DOI：
10.1023/a:1016243710507
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发表时间：
2002-06-01
影响因子：
3
通讯作者：
Turk, DC
中科院分区：
文献类型：
--
作者：
Okifuji, A;Turk, DC
纤维肌痛综合征（FMS）是一种常见的肌肉骨骼疼痛疾病，其特征是弥漫性疼痛和相关的心理生理症状。尽管在过去的30年中进行了广泛的研究，但FMS的病因和病理生理学以及有效的治疗方法尚未被描述。最近，有研究表明，FMS可能与功能低下的应激系统，特别是在自主神经系统（ANS）和下丘脑-垂体-肾上腺（HPA）轴。研究表明，FMS患者表现出对应激的交感肾上腺反应性降低。这些发现似乎与大量的研究结果一致，表明疼痛敏感性和交感神经反应之间的反比关系。在本文中，我们讨论了压力的作用，在疼痛的经验一般，压力与FMS患者，并审查研究评估的ANS和HPA功能，以应对各种压力。
Fibromyalgia syndrome (FMS) is a prevalent musculoskeletal pain disorder characterized by diffuse pain and associated psychophysiological symptoms. Despite extensive research in the past 3 decades, the etiology and pathophysiology of FMS and effective treatment approaches are yet to be delineated. Recently, it has been suggested that FMS may be related to hypofunctional stress systems, particularly in the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis. Studies have demonstrated that patients with FMS exhibit lowered sympathoadrenal reactivity to stress. These findings seem to be consistent with the large volume of research indicating the inverse relationship between pain sensitivity and sympathetic reactivity. In this paper, we discuss the role of stress in the pain experience in general, stress in patients with FMS, and review the studies evaluating the ANS and HPA functions in response to various stressors.