Effect of coronary blood flow and site of injection on Tc-99m PPi detection of early canine myocardial infarcts.
Effect of coronary blood flow and site of injection on Tc-99m PPi detection of early canine myocardial infarcts.
复制标题
冠状动脉血流和注射部位对早期犬心肌梗塞 Tc-99m PPi 检测的影响。
DOI：
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发表时间：
1981
影响因子：
9.3
通讯作者：
J. Willerson
中科院分区：
文献类型：
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作者：
R. Parkey;P. Kulkarni;S. Lewis;F. Datz;G. Dehmer;D. P. Gutekunst;L. Buja;F. Bonte;J. Willerson
在24条狗上研究了血流量和注射部位对急性心肌梗塞摄取Tc-99 mPPi的影响。使用临时（3小时）和永久性LAO闭塞模型。与永久性冠状动脉闭塞的动物相比，暂时性闭塞的动物显示梗死的血流显像和正常表位-内皮素Tc-99 m PPi比率的逆转。这些数据表明，早期（3小时内）实验犬心肌梗死可以检测到Tc-99 m PPi，如果回流到梗死区提供。急性梗死异常Tc-99 m PPi血流图的延迟发展主要与受损组织最初缺乏足够的血流有关，随后发展出足够的侧支血流，允许输送和摄取足量的放射性药物，用于受损区域的体内血流图检测。
The effect of blood flow and site of injection on Tc-99m PPi uptake in acute myocardial infarction was studied in a group of 24 dogs. Temporary (3 hr) and permanent LAO occlusion models were used. Animals with the temporary occlusions showed scintigraphic visualization of the infarcts and reversal of the normal epito-endocardial Tc-99m PPi ratio in contrast to those with permanent coronary occlusions. The data demonstrate that early (within 3 hr) experimental canine myocardial infarcts can be detected with Tc-99m PPi if reflow to the area of infarction is provided. Delayed development of abnormal Tc-99m PPi scintigrams with acute infarction is related primarily to the initial lack of adequate blood flow to the damaged tissue, with subsequent development of adequate collateral flow allowing delivery and uptake of sufficient amount of the radiopharmaceutical for in vivo scintigraphic detection of the damaged area(s).