Research Domain Criteria versus DSM V: How does this debate affect attempts to model corticostriatal dysfunction in animals?
Research Domain Criteria versus DSM V: How does this debate affect attempts to model corticostriatal dysfunction in animals?
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DOI：
10.1016/j.neubiorev.2016.10.029
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发表时间：
2017-05-01
影响因子：
8.2
通讯作者：
Hall, Frank Scott
中科院分区：
文献类型：
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作者：
Young, Jared W.;Winstanley, Catharine A.;Hall, Frank Scott
几十年来，精神疾病的分类学在很大程度上是基于美国精神病学协会（DSM）的诊断和统计手册中的描述。最近，美国国家心理健康研究所（National Institute on Mental Health， USA）对DSM精神病学方法提出了挑战，将研究领域标准（RDoC）定义为一种替代方法。对于RDoC来说，精神疾病并没有被定义为独立的类别，而是与DSM诊断类别无关的特定行为功能障碍。这种方法是由DSM中指出的两个主要弱点驱动的：(1)相同的症状出现在非常不同的疾病状态中；(2) DSM标准缺乏精神疾病的潜在生物学原因基础。RDoC打算将精神病学建立在这些潜在机制的基础上。本文从动物精神疾病建模的角度探讨了RDoC与DSM的适用性。考虑所有类型的精神功能障碍超出了本综述的范围，本文将重点关注与额纹状体功能障碍相关的疾病模型。(C) 2016年Elsevier Ltd.出版
For decades, the nosology of mental illness has been based largely upon the descriptions in the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM). A recent challenge to the DSM approach to psychiatric nosology from the National Institute on Mental Health (USA) defines Research Domain Criteria (RDoC) as an alternative. For RDoC, psychiatric illnesses are not defined as discrete categories, but instead as specific behavioral dysfunctions irrespective of DSM diagnostic categories. This approach was driven by two primary weaknesses noted in the DSM: (1) the same symptoms occur in very different disease states; and (2) DSM criteria lack grounding in the underlying biological causes of mental illness. RDoC intends to ground psychiatric nosology in those underlying mechanisms. This review addresses the suitability of RDoC vs. DSM from the view of modeling mental illness in animals. A consideration of all types of psychiatric dysfunction is beyond the scope of this review, which will focus on models of conditions associated with frontostriatal dysfunction. (C) 2016 Published by Elsevier Ltd.