Early-life indoor environmental exposures increase the risk of childhood asthma
Early-life indoor environmental exposures increase the risk of childhood asthma
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DOI：
10.1016/j.ijheh.2011.07.004
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发表时间：
2011-12-01
影响因子：
6
通讯作者：
Lee, Yungling Leo
中科院分区：
文献类型：
--
作者：
Chen, Yang-Ching;Tsai, Ching-Hui;Lee, Yungling Leo
我们旨在探讨台湾儿童早期接触潮湿、宠物和环境烟草烟雾(ETS)与哮喘之间的关系，并讨论它们与早发和晚发哮喘的联系。我们从台湾儿童健康研究中进行了1：2匹配的病例对照研究，这是一项全国性的研究，招募了14个社区的12至14岁的学龄儿童。579名参与者的母亲接受了电话采访，了解他们的孩子在5岁之前暴露在环境中的情况，包括宫内时期。儿童哮喘与早期生活环境因素有关，如蟑螂(OR=2.16；95%CI，1.15~4.07)、可见霉菌(OR=1.75；95%CI，1.15~2.67)、霉味(OR=5.04：95%CI，2.42~10.50)、地毯(OR=2.36；95%CI，1.38~4.05)、宠物(OR=2.11；95%氯，1.20~3.72)，每天服药1小时以上(OR=1.93；95%氯，1.16~3.23)。在晚发性哮喘的儿童中，儿童早期的霉味、羽毛枕头和ETS的OR值更大。蟑螂、地毯、宠物和宫内暴露于ETS会影响早发哮喘的发生时间。暴露于这些因素会导致哮喘风险的剂量反应关系。而较早的暴露可能会触发较早的发病。避免这些环境暴露的干预措施对于早期预防儿童哮喘是必要的。(C)2011年爱思唯尔股份有限公司。版权所有。
We aim to explore the relationships between exposure to dampness, pets, and environmental tobacco smoke (ETS) early in life and asthma in Taiwanese children, and to discuss their links to early- and late-onset asthma. We conducted a 1:2 matched case-control study from the Taiwan Children Health Study, which was a nationwide study that recruited 12-to-14 year-old school children in 14 communities. The 579 mothers of the participants were interviewed by telephone about their children's environmental exposures before they were 5 years old, including the in-utero period. Childhood asthma was associated with exposure to early life environmental factors, such as cockroaches (OR = 2.16; 95% Cl, 1.15-4.07), visible mould (OR = 1.75; 95% Cl, 1.15-2.67), mildewy odors (OR = 5.04:95% Cl, 2.42-10.50), carpet (OR = 2.36; 95% Cl, 1.38-4.05), pets (OR = 2.11; 95% Cl, 1.20-3.72), and more than one hour of ETS per day (OR = 1.93; 95% Cl, 1.16-3.23). The ORs for mildewy odors, feather pillows, and ETS during early childhood were greater among children with late-onset asthma. Cockroaches, carpet, pets, and in-utero exposures to ETS affected the timing of early-onset asthma. Exposure to these factors led to dose-responsiveness in the risk of asthma. And the earlier exposures may trigger the earlier onset. Interventions in avoiding these environmental exposures are necessary for early-prevention of childhood asthma. (C) 2011 Elsevier GmbH. All rights reserved.