Availability of aluminum from glass and an Al form ion exchanger in the presence of complexing agents and amino acids
Availability of aluminum from glass and an Al form ion exchanger in the presence of complexing agents and amino acids
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DOI：
10.1016/s0003-2670(02)00111-3
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发表时间：
2002-05-22
影响因子：
6.2
通讯作者：
Binotto, R
中科院分区：
文献类型：
--
作者：
Bohrer, D;do Nascimento, PC;Binotto, R
铝可以作为污染物存在于肠外营养氨基酸溶液中。这是一个问题，因为这些溶液被直接引入循环电流，铝对一些病人，主要是早产儿有毒性作用。氨基酸可以负责铝污染的非注射溶液，当他们储存在玻璃容器。玻璃可以是铝的来源，因为铝存在于其成分中以提高耐化学性。在这项工作中，玻璃与铝离子的一种可用来源进行了比较，铝离子是一种Al3+形式的阳离子交换剂。用于肠外营养的氨基酸溶液单独放置，分别与玻璃粉和交换剂接触。这些溶液的铝含量在储存后的60天内被测量。对铝离子、乙二胺四乙酸（EDTA）、硝基三乙酸（NTA）、柠檬酸盐和草酸盐离子具有强亲和力的物质溶液也进行了测试。测定方法为原子吸收光谱法。结果表明，具有极性侧链的氨基酸能够从玻璃和离子交换树脂中提取铝，氨基酸溶液与玻璃表面的相互作用方式与与交换剂的相互作用方式相同。玻璃和交换剂的萃取率依次为鸟氨酸>天冬氨酸>赖氨酸>谷氨酸> n -乙酰基酪氨酸→丝氨酸→酪氨酸→精氨酸。玻璃和树脂络合剂的结果也类似，由此可以得出，铝络合剂的稳定常数越高，铝的提取率越高。该研究还表明，一些氨基酸能够与玻璃表面相互作用。氨基酸与Cu2+形式交换剂的相互作用证实了金属萃取速率与配合物稳定性之间的关系。玻璃容器内的肠外营养液受铝污染的原因可归结为玻璃的离子交换特性和某些氨基酸对铝离子的亲和力。(C) 2002 Elsevier Science B.V.版权所有
Aluminum can exist as contaminant in solutions of amino acids used for parenteral nutrition. It is a problem because these solutions are introduced directly into the circulatory current and aluminum shows toxic effects for some patients, mainly pre-term infants. Amino acids can be responsible for the aluminum contamination of parenteral solutions when they are stored in glass containers. Glass can be a source of aluminum because aluminum is present in its composition to improve chemical resistance. In this work, glass was compared with an available source of aluminum ions, a cation exchanger in Al3+ form. Solutions of amino acids used in parenteral nutrition were placed individually and separately in contact with glass powder and exchanger. The aluminum content of these solutions was measured for up to 60 days after storage. Solutions of species that have strong affinity for aluminum ions, ethylene diaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA) and citrate and oxalate ions were also tested. The measurements were made by atomic absorption spectrometry. The results showed that amino acids with polar lateral chains were able to extract aluminum from both glass and ion-exchange resin and the interaction of the amino acid solutions with the glass surface occurs in the same way as with the exchanger. The sequence ornithine > aspartic acid > lysine > glutamic acid > N-acetyltyrosine congruent to serine congruent to tyrosine congruent to arginine, was found for both glass and exchanger for extraction rates put in decreasing order. The results for complexing agents were also similar for glass and resin, from which it could be concluded that the higher the stability constant of the aluminum complex, the higher the amount of aluminum extracted. The study also showed that some amino acids are able to interact with a glass surface. Interaction of amino acids with an Cu2+ form exchanger confirmed the relation between metal extraction rates and complex stability. The contamination by aluminum of parenteral nutrition solutions stored in glass containers can be attributed to the combination of the ion exchange property of glass and the affinity of some amino acids for this metal ion. (C) 2002 Elsevier Science B.V. All rights reserved.