Description and nomenclature of Neisseria meningitidis capsule locus.
Description and nomenclature of Neisseria meningitidis capsule locus.
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DOI：
10.3201/eid1904.111799
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发表时间：
2013-04
影响因子：
11.8
通讯作者：
Maiden MC
中科院分区：
文献类型：
--
作者：
Harrison OB;Claus H;Jiang Y;Bennett JS;Bratcher HB;Jolley KA;Corton C;Care R;Poolman JT;Zollinger WD;Frasch CE;Stephens DS;Feavers I;Frosch M;Parkhill J;Vogel U;Quail MA;Bentley SD;Maiden MC
致病性脑膜炎奈瑟菌分离株含有多糖荚膜，这是该细菌的主要毒力决定因素。已经描述了13种荚膜多糖，并且核磁共振光谱已经能够确定负责血清群特异性的荚膜多糖的结构。N.还鉴定了脑膜炎荚膜生物合成，参与该过程和细胞表面易位的基因聚集在称为CPS的单个染色体基因座。使用多个名称的一些基因参与胶囊的合成，结合需要快速诊断血清型通常与侵袭性脑膜炎球菌疾病，提示需要一个一致的方法来命名胶囊基因。本文对我国所有的N.提供了脑膜炎球菌血清群的分类，沿着了在2012年第XVIII届国际病原性奈瑟氏球菌会议上提出的建议命名法。
Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.