The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.
The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.
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DOI：
10.1016/j.cell.2016.05.004
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发表时间：
2016-05-19
期刊：
影响因子：
64.5
通讯作者：
Fuxreiter M
中科院分区：
文献类型：
--
作者：
Wu H;Fuxreiter M
在这里，我们试图达到一个综合的理解的结构和动力学的一些高阶组件，包括淀粉样蛋白，各种信号体，和细胞颗粒。我们建议，折叠域，线性图案和内在无序的区域之间的协同作用，调节所有高阶组件的形成和内在的融合，创造一个结构和动态的连续体。我们描述了这种调节机制如何在病理条件下受到影响。
We here attempt to reach an integrated understanding of the structure and dynamics of a number of higher-order assemblies including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs and intrinsically disordered regions regulates formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.