Targeting Tumors with Small Molecule Peptides.
Targeting Tumors with Small Molecule Peptides.
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DOI：
10.2174/1568009616666151130214646
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发表时间：
2016
影响因子：
3
通讯作者：
Cui H
中科院分区：
文献类型：
--
作者：
Cheetham AG;Keith D;Zhang P;Lin R;Su H;Cui H
癌症的化疗是一项具有挑战性的努力，因为对肿瘤组织的选择性低于对健康组织的选择性。优先将一种给定的药物输送到肿瘤部位需要使用靶向元件，而靶向元件的开发范围很广。在这篇综述中，我们重点介绍了最近基于多肽的靶向配体的例子，这些配体已经被利用来选择性地将化疗有效载荷输送到特定的肿瘤相关部位，如血管、淋巴管或细胞表面。将讨论这些方法的优点和局限性，以期在未来有可能的发展。此外，我们还将研究基于多肽的配体如何通过将其掺入显像剂而用于癌症的诊断和表征。
Chemotherapeutic treatment of cancers is a challenging endeavor, hindered by poor selectivity towards tumorous tissues over healthy ones. Preferentially delivering a given drug to tumor sites necessitates the use of targeting elements, of which there are a wide range in development. In this Review, we highlight recent examples of peptide-based targeting ligands that have been exploited to selectively deliver a chemotherapeutic payload to specific tumor-associated sites such as the vasculature, lymphatics, or cell surface. The advantages and limitations of such approaches will be discussed with a view to potential future development. Additionally, we will also examine how peptide-based ligands can be used diagnostically in the detection and characterization of cancers through their incorporation into imaging agents.