The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly
The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly
复制标题
DOI：
10.1007/s11745-009-3281-y
复制
发表时间：
2009-05-01
期刊：
影响因子：
1.9
通讯作者：
Lind, Lars
中科院分区：
文献类型：
--
作者：
Andersson, Jessika;Sundstrom, Johan;Lind, Lars
颈动脉斑块可以通过超声的大小和回声来表征。大小和回声都是心血管事件的预测因子。本研究的目的是检查传统的危险因素和炎症及氧化标记物是否与斑块大小和回声有关。在一项基于人群的健康调查（PIVUS研究）中，通过超声对1,016名70岁受试者的颈动脉斑块大小和回声（灰度中值，GSM）进行了计算机分析。收集了心血管危险因素的信息，以及炎症和氧化的标志物。斑块的发生与心脏病危险度评分、收缩压、BMI、HDL、谷胱甘肽水平有关。以前或现在吸烟是常见的显着更多包年相关的echorich斑块。斑块大小与脆性风险评分增加、收缩压、血糖水平、吸烟、ApoB/A1比值、OxLDL、TNF α、HOMA胰岛素抵抗、白细胞计数、BCD-LDL降低和低水平L-选择素相关。低HDL、BMI增加和谷胱甘肽水平降低与颈动脉斑块的回声透明性相关，这意味着代谢因素对斑块组成起作用。炎症标志物仅与斑块大小相关，这意味着炎症主要与动脉粥样硬化的数量相关。这些结果表明斑块大小和回声强度受不同危险因素的影响。
Carotid plaques can be characterised by ultrasound by size and echogenicity. Both size and echogenicity are predictors of cardiovascular events. The aim of this study was to examine whether traditional risk factors and markers of inflammation and oxidation were associated with plaque size and echogenicity. Computerised analysis of carotid plaque size and echogenicity (grey scale median, GSM) were performed by ultrasound in a population-based health survey in 1,016 subjects aged 70 years (PIVUS study). Information on cardiovascular risk factors was collected, together with markers of inflammation and oxidation. Increased Framingham risk score, systolic blood pressure, higher BMI and decreased HDL, lower glutathione levels were related to echolucent plaques. Previous or present smoking was common with significantly more pack-years related to the echorich plaques. Plaque size was associated with increased Framingham risk score, systolic blood pressure, blood glucose levels, smoking, ApoB/A1 ratio, OxLDL, TNF alpha, HOMA insulin resistance, leucocyte count, decreased BCD-LDL and low levels of l-selectin. Low HDL, increased BMI and decreased glutathione levels were associated with the echolucency of carotid plaques, implying metabolic factors to play a role for plaque composition. Markers of inflammation were related to plaque size alone, implying inflammation to be predominantly associated with the amount of atherosclerosis. These results suggest that plaque size and echogenicity are influenced by different risk factors.