The pre-Botzinger oscillator in the mouse embryo
The pre-Botzinger oscillator in the mouse embryo
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DOI：
10.1016/j.jphysparis.2007.05.007
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发表时间：
2006-11-01
影响因子：
--
通讯作者：
Fortin, G.
中科院分区：
文献类型：
--
作者：
Borday, C.;Vias, C.;Fortin, G.
对哺乳动物呼吸节律产生所涉及的位点和机制的研究表明，脑干内有两簇节律神经元形成耦合振荡网络。这些振荡器的位置，迷走神经水平的前博辛格复合体（preBotC）和面部水平的面旁呼吸群，可能是由胚胎发生过程中后脑神经类型指定的区域模式方案产生的。在这里，我们报告了以下证据：preBotC 振荡器 (i) 在胚胎阶段首先活跃，(ii) 起源于耳后后脑神经管，(iii) 需要谷氨酸囊泡转运蛋白 2 来产生节律。 (c) 2007 Elsevier Ltd. 保留所有权利。
Studies of the sites and mechanisms involved in mammalian respiratory rhythm generation point to two clusters of rhythmic neurons forming a coupled oscillator network within the brainstem. The location of these oscillators, the pre-Botzinger complex (preBotC) at vagal level, and the para-facial respiratory group at facial level, probably result from regional patterning schemes specifying neural types in the hindbrain during embryogenesis. Here, we report evidence that the preBotC oscillator (i) is first active at embryonic stages, (ii) originates in the post-otic hindbrain neural tube and (iii) requires the glutamate vesicular transporter 2 for rhythm generation. (c) 2007 Elsevier Ltd. All rights reserved.