GATB: Genome Assembly & Analysis Tool Box.

GATB: Genome Assembly & Analysis Tool Box.
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DOI:
10.1093/bioinformatics/btu406
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发表时间:
2014-10-15
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
通讯作者:
Lavenier D
Lavenier D
中科院分区:
其他
文献类型:
--
作者:
Drezen E;Rizk G;Chikhi R;Deltel C;Lemaitre C;Peterlongo P;Lavenier D

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动机:高效快速的下一代测序(NGS)算法对于分析NGS机器生成的TB级数据至关重要。一个严重的瓶颈可能是这种算法的设计,因为它们需要复杂的数据结构和先进的硬件实现。结果:我们提出了一个致力于基因组组装和分析的开源库,以加快开发高效软件的过程。该库基于最近优化的de-Bruijn图实现,允许在台式计算机上使用快速算法以低内存占用处理复杂的基因组。可用性和实现:GATB库是用C++编写的,可以在以下网站上获得:http://gatb.inria.fr,并遵循A-GPL许可证。联系方式:lavenier@irisa.fr补充信息:补充数据可在生物信息学在线获得。
Motivation: Efficient and fast next-generation sequencing (NGS) algorithms are essential to analyze the terabytes of data generated by the NGS machines. A serious bottleneck can be the design of such algorithms, as they require sophisticated data structures and advanced hardware implementation. Results: We propose an open-source library dedicated to genome assembly and analysis to fasten the process of developing efficient software. The library is based on a recent optimized de-Bruijn graph implementation allowing complex genomes to be processed on desktop computers using fast algorithms with low memory footprints. Availability and implementation: The GATB library is written in C++ and is available at the following Web site http://gatb.inria.fr under the A-GPL license. Contact: lavenier@irisa.fr Supplementary information: Supplementary data are available at Bioinformatics online.
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