Antiretroviral regimen and suboptimal medication adherence are associated with low-level human immunodeficiency virus viremia.
Antiretroviral regimen and suboptimal medication adherence are associated with low-level human immunodeficiency virus viremia.
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DOI：
10.1093/ofid/ofu119
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发表时间：
2015-01
影响因子：
4.2
通讯作者：
Li JZ
中科院分区：
文献类型：
--
作者：
Konstantopoulos C;Ribaudo H;Ragland K;Bangsberg DR;Li JZ
人类免疫缺陷病毒低水平病毒血症(LLV)的发作在临床环境中很常见，但其与抗逆转录病毒治疗(ART)方案和依从性的关系尚不清楚。通过未公布的药片计数来评估无家可归者队列中获得护理的研究的参与者的抗逆转录病毒治疗依从性。与LLV风险增加相关的因素包括使用基于蛋白水解酶抑制物(PI)的治疗方案(利托那韦促进的PI与非核苷逆转录酶抑制物：调整后的风险比[HR]，3.1；P=.01)和过去3个月较低的ART依从性(HR，依从性每减少5%，调整后为1.1；P=.050)。LLV患者可以从ART依从性咨询和潜在的方案修改中受益。
Episodes of human immunodeficiency virus low-level viremia (LLV) are common in the clinical setting, but its association with antiretroviral therapy (ART) regimen and adherence remains unclear. Antiretroviral therapy adherence was evaluated in participants of the Research on Access to Care in the Homeless cohort by unannounced pill counts. Factors associated with increased risk of LLV include treatment with a protease inhibitor (PI)-based regimen (ritonavir-boosted PI vs nonnucleoside reverse-transcriptase inhibitor: adjusted hazard ratio [HR], 3.1; P = .01) and lower ART adherence over the past 3 months (HR, 1.1 per 5% decreased adherence, adjusted; P = .050). Patients with LLV may benefit from ART adherence counseling and potentially regimen modification.
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影响因子：
3.8
作者：
Bangsberg, DR;Perry, S;Moss, A
通讯作者：
Moss, A
影响因子：
6.4
作者：
Podsadecki, Thomas J.;Vrijens, Bernard C.;Hanna, George J.
通讯作者：
Hanna, George J.
DOI：
10.1073/pnas.1318249111
发表时间：
2014-02-11
影响因子：
11.1
作者：
Fletcher, Courtney V.;Staskus, Kathryn;Schacker, Timothy W.
通讯作者：
Schacker, Timothy W.
影响因子：
3.8
作者：
Karlsson, AC;Younger, SR;Deeks, SG
通讯作者：
Deeks, SG
影响因子：
3.8
作者：
Bangsberg, DR;Hecht, FM;Moss, A
通讯作者：
Moss, A