Brain endorphins: possible mediators of pleasurable states
Brain endorphins: possible mediators of pleasurable states
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脑内啡肽：愉悦状态的可能调节者
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
J. Belluzzi
中科院分区：
文献类型：
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作者：
L. Stein;J. Belluzzi
目前的概念（Kosterlitz和Hughes，1975;阿基勒和Liebeskind，1975; Snyder，1975）关于内啡肽作为调节疼痛反应的天然镇痛物质的观点可能是正确的（Belluzzi等，1976），但这些制剂太窄，不能适应这些肽在精神疾病中的假定作用（Bloom等，1976; Terenius等，1976）。我们在这里提出了一个扩展的功能归因于内啡肽沿着以前建议的路线（Goldstein，1976; Byck，1976; Belluzzi和Stein，1977 a），包括调节情感状态和食欲驱动。更确切地说，我们认为内啡肽可能作为神经系统的递质或调制器，用于调节快乐和奖励。奖励功能障碍是情感障碍和精神分裂症的病因的可能性在其他地方已经被考虑过（Stein，1962; Stein和Wise，1971）。
Present conceptions (Kosterlitz and Hughes, 1975; Akil and Liebeskind, 1975; Snyder, 1975) of endorphins as natural analgesic substances for regulation of the response to pain are probably correct (Belluzzi et al. 1976), but these formulations are too narrow to accommodate the role postulated for these peptides in mental disease (Bloom et al. 1976; Terenius et al. 1976). We propose here a broadening of the functions attributed to endorphins—along lines previously suggested (Goldstein, 1976; Byck, 1976; Belluzzi and Stein, 1977a)—to include the regulation of affective states and appetitive drives. More precisely, we suggest that endorphins may serve as transmitters or modulators in neuronal systems for the mediation of pleasure and reward. The possibility that reward dysfunction is an etiological factor in affective disorders and schizophrenia has been considered elsewhere (Stein, 1962; Stein and Wise, 1971).