PREVALENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION IN A HUMAN-POPULATION OF ARGENTINA
PREVALENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION IN A HUMAN-POPULATION OF ARGENTINA
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DOI：
10.4269/ajtmh.1994.50.381
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发表时间：
1994-03-01
影响因子：
3.3
通讯作者：
MAIZTEGUI, JI
中科院分区：
文献类型：
--
作者：
AMBROSIO, AM;FEUILLADE, MR;MAIZTEGUI, JI
淋巴细胞性脉络丛脑膜炎病毒（LCMV）在阿根廷出血热流行区的活动已被报道，并代表了两种沙粒病毒对人类的致病性，朱宁和LCMV，在同一地理区域共存的第一个证据。提供了阿根廷圣菲省10，000平方公里地区LCMV人类感染流行率的数据。研究对象为15-65岁的男性，生活和/或工作在41个地区的农村地区。从21，340名具有所述特征的个体的总人群中的7，227名志愿者中的每一个获得一份血清样品。通过间接免疫荧光试验评估LCMV抗体。在172份血清样品中发现了这些抗体，其滴度范围为1：8至1：128（几何平均滴度= 15.03），平均感染百分比为2.38%。东、西边界阳性率分别为1.54%和3.07%，差异有统计学意义（P < 0.0003）。西部感染率较高是由于存在两个县群，平均感染率为6.06%，与研究区其他地区的1.67%有显著差异（P < 0.0003）。这些结果提供了新的信息LCMV活动在阿根廷，并更新的证据在阿根廷的同一地区的两个沙粒病毒的共存。这种情况增加了产生具有变化的病毒抑制剂的可能性，这些变化可以确定对沙粒病毒疾病的新治疗和/或预防策略的需求。
The activity of lymphocytic choriomeningitis virus (LCMV) in the endemic area of Argentine hemorrhagic fever has been previously reported and represents the first evidence of the coexistence of two arenaviruses pathogenic for humans, Junin and LCMV, in the same geographic area. Data are presented on the prevalence of LCMV human infection in a 10,000-km(2) area located in Santa Fe Province, Argentina. Study subjects were males, 15-65 years old, living and/or working in the rural area of 41 localities. One serum sample was obtained from each of 7,227 volunteers from a total population of 21,340 individuals with the described features. Antibodies to LCMV were assessed by means of an indirect immunofluorescence assay. These antibodies were found in 172 serum samples, with titers ranging from 1:8 to 1:128 (geometric mean titer = 15.03), and a mean percentage of infection of 2.38%. A significantly different distribution of positive individuals was found between the eastern (1.54%) and western (3.07%) borders of the region studied (P < 0.0003). The higher percentage of infection on the western side was due to the existence of two clusters of counties with a mean percentage of 6.06% that was significantly different from the 1.67% obtained in the rest of the study area (P < 0.0003). These results provide new information on the LCMV activity in Argentina, and update the evidence on the coexistence of two arenaviruses in the same region of Argentina. This circumstance increases the probability of generation of viral reassortants with changes that could determine the need for new therapeutic and/or preventive strategies for arenaviral diseases.