Textile cell-free scaffolds for in situ tissue engineering applications.
Textile cell-free scaffolds for in situ tissue engineering applications.
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DOI：
10.1007/s10856-015-5656-3
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Cherif C
中科院分区：
文献类型：
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作者：
Aibibu D;Hild M;Wöltje M;Cherif C
在本文中，讨论了通过纺织品制造技术制造的微纤维支架结构所提供的好处：如何利用现有的和新颖的纤维加工技术来生成满足目标细胞生态位需求的模板？解决了与开发可用于纺织品制造的生物材料纤维（特别是来自天然材料）相关的问题。还关注如何通过混合制造方法（例如纳米纤维或水凝胶功能化）将生物线索纳入微纤维支架结构中。在对最近用于原位 TE 的无细胞纤维支架的示范性研究工作（包括临床研究）进行严格审查后，我们得出结论，为了利用工程纤维支架系统可能提供的全部优势，需要解决四个主要问题：（1）制造技术和材料的逻辑组合。 (2)生物材料纤维开发。 (3) 纺织品制造技术适应再生医学支架的需求。 (4) 生物线索的纳入（例如干细胞归巢因子）。
In this article, the benefits offered by micro-fibrous scaffold architectures fabricated by textile manufacturing techniques are discussed: How can established and novel fiber-processing techniques be exploited in order to generate templates matching the demands of the target cell niche? The problems related to the development of biomaterial fibers (especially from nature-derived materials) ready for textile manufacturing are addressed. Attention is also paid on how biological cues may be incorporated into micro-fibrous scaffold architectures by hybrid manufacturing approaches (e.g. nanofiber or hydrogel functionalization). After a critical review of exemplary recent research works on cell-free fiber based scaffolds for in situ TE, including clinical studies, we conclude that in order to make use of the whole range of favors which may be provided by engineered fibrous scaffold systems, there are four main issues which need to be addressed: (1) Logical combination of manufacturing techniques and materials. (2) Biomaterial fiber development. (3) Adaption of textile manufacturing techniques to the demands of scaffolds for regenerative medicine. (4) Incorporation of biological cues (e.g. stem cell homing factors).