The actual survival rate in systemic lupus erythematosus: Study of a 1976 cohort
The actual survival rate in systemic lupus erythematosus: Study of a 1976 cohort
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系统性红斑狼疮的实际生存率：1976 年队列研究
DOI：
10.1007/bf02208691
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发表时间：
1991
影响因子：
3.4
通讯作者：
M. Kahn
中科院分区：
文献类型：
--
作者：
M. Breban;O. Meyer;P. Bourgeois;E. Palazzo;M. Kahn
本研究的目的是建立一个队列的51例系统性红斑狼疮（SLE）患者的实际生存率，所有这些人都在12年期间，从1976年至1988年，以评估严重并发症的疾病的预后意义。48名为女性。发病时平均年龄为28.5岁，诊断时平均年龄为36.2岁，入组时平均年龄为42岁; 80%的患者在诊断时有4个或更多1982年ARA标准，1988年为96%。生存率为：2年96%，5年86.3%，12年74.5%。主要死亡原因为感染（62%），仅1例为SLE直接死亡。在几乎三分之二的病例中，被认为是严重的表现在足以识别疾病不同严重形式的时间内没有任何一致性。
The purpose of this study was to establish the actual survival rate of a cohort of 51 patients with systemic lupus erythematosus (SLE) all of whom were followed during 12 years from 1976 to 1988 and to evaluate the prognostic significance of the severe complications of the disease. Forty-eight were females. The mean age was 28.5 at onset, 36.2 at diagnosis and 42 at entry; 80% had four or more 1982 ARA criteria at diagnosis and 96% in 1988. Survival rates were: 96% at two years, 86.3% at five years and 74.5% at twelve years. The main cause of death was infection (62%); SLE was directly responsible in only one case. Manifestations considered as severe occurred in almost two-thirds of the cases without any concordance in the time sufficient to recognize different severe forms of the disease.