c-fos expression as a tool to search for the neurobiological base of the sexual behaviour of males
c-fos expression as a tool to search for the neurobiological base of the sexual behaviour of males
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DOI：
10.55782/ane-1996-1162
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发表时间：
1996-01-01
影响因子：
1.4
通讯作者：
Kaczmarek, L
中科院分区：
文献类型：
--
作者：
Bialy, M;Kaczmarek, L
在用各种刺激激活脑细胞后，反复观察到c-fos mRNA和/或其蛋白（c-Fos）的表达升高。因此，有人提出，c-fos表达升高可作为神经元活化的标志物，反映细胞功能长期变化的倾向（神经元可塑性）。在雄性动物交配行为的研究中，Fos免疫反应性升高（最可能与c-Fos相关）已被许多研究人员用作揭示行为的功能神经解剖学的工具。他们发现，在各种物种中，诸如内侧视前区（MPOA）、终纹床核（BNST）、内侧杏仁核（MeAm）和中央被盖区（CTF）等大脑区域总是以交配依赖的方式被激活（大鼠和仓鼠是这方面最常研究的）。本文回顾了在这一领域收集的数据，并讨论了他们的背景下，提高Fos表达的作用收购与性能的性行为。
Elevated expression of c-fos mRNA and/or its protein (c-Fos) has been repeatedly observed following activation of brain cells with various stimuli. As a consequence it has been proposed that elevated c-fos expression may serve as a marker of neuronal activation reflecting a predisposal to long-term changes in cell functioning (neuronal plasticity). In studies on copulatory behaviour of male animals, elevated Fos immunoreactivity (related most probably to c-Fos) has been used by many researchers as a tool to reveal functional neuroanatomy of the behaviour. They found that brain regions such as medial preoptic area (MPOA), bed nucleus of stria terminalis (BNST), medial amygdala (MeAm) and central tegmental field (CTF) are always activated in a copulation-dependent manner in various species (rats and hamsters were the most often studied in this regard). This paper reviews the data gathered in this field, and discusses them in the context of a role of elevated Fos expression in acquisition vs. performance of the sexual behaviour.