Classifying the intensity of pediatric cancer treatment protocols: The intensity of treatment rating scale 2.0 (ITR-2)
Classifying the intensity of pediatric cancer treatment protocols: The intensity of treatment rating scale 2.0 (ITR-2)
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DOI：
10.1002/pbc.21184
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发表时间：
2007-06-15
影响因子：
3.2
通讯作者：
Meadows, Anna T.
中科院分区：
文献类型：
--
作者：
Werba, Branlyn E.;Hobbie, Wendy;Meadows, Anna T.
背景。开发和验证一种使用四个操作定义的治疗强度类别来对小儿肿瘤治疗的强度进行分类的方法。程序。评级量表的早期版本，即治疗评级的强度（ITR），分为两个阶段进行了修订和验证。在规模施工阶段，三个标准评估者根据小儿肿瘤学家评估者的共识和项目协议数据修订了ITR项目（n = 15）。在规模验证阶段，新的ITR-2项目使用我们机构外部的第二组儿科肿瘤学家进行了验证（n = 12）。此外，采用第三组评估者（n = 16）来评估12例患者的评价者间可靠性，以不同水平的治疗强度。结果。 ITR-2上所有34个项目的标准评级和外部评估中位数之间的一致性非常高（r = 0.95，范围0.71-0.91）。当使用ITR-2评估12个患者示例时，儿科肿瘤学家之间的评价者一致性也很高（标准 - 理由配对之间的中位数一致：r = 0.87； 16个评分者之间的总体相关性：R（ICC）= 0.83 ）。结论。修订后的ITR量表2.0（ITR-2）是对小儿肿瘤治疗强度进行分类的有效且可靠的量表。 Pediatr Blood Cancer 2007; 48：673-677。 （c）2007 Wiley-Liss，Inc。
Background. To develop and validate a method of classifying the intensity of pediatric oncology treatments using four operationally defined categories of treatment intensity. Procedure. An earlier version of a rating scale, the intensity of treatment rating (ITR), was revised and validated in two phases. In the Scale Construction phase, three criterion raters revised the ITR items based on consensus and item agreement data from pediatric oncologist raters (N = 15). In the Scale Validation phase, the new ITR-2 items were validated using a second set of pediatric oncologists external to our institution (N = 12). In addition, a third group of raters (N = 16), was employed to assess inter-rater reliabilities for 12 patients at varying levels of treatment intensities. Results. Agreement between criterion ratings and the median of external raters for all 34 items on the ITR-2 was very high (r = 0.95, range 0.71-0.91). When the ITR-2 was used to rate 12 patient examples, the inter-rater agreement among pediatric oncologists was also very high (median agreement between criterion-rater pairs: r = 0.87; overall relatedness among 16 raters: r(ICC) = 0.83). Conclusions. The revised ITR Scale 2.0 (ITR-2) is a valid and reliable scale for classifying the intensity of pediatric oncology treatments. Pediatr Blood Cancer 2007;48:673-677. (c) 2007 Wiley-Liss, Inc.