Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes
Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes
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DOI：
10.1002/ajmg.b.30436
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发表时间：
2006-12-05
影响因子：
2.8
通讯作者：
Uhl, George R.
中科院分区：
文献类型：
--
作者：
Liu, Qing-Rong;Drgon, Tomas;Uhl, George R.
成瘾实质上是一种遗传的复杂疾病。我们现在报告全基因组关联研究，鉴定出89个基因可能包含导致成瘾脆弱性的变异，使用先前和新验证的基于微阵列的池化分析。每个基因都含有聚集性单核苷酸多态性（SNP），在研究的两个样本中，滥用者和对照组之间的等位基因频率存在显著差异，其中639,401个SNP阵列和来自其他两个滥用者/对照样本的验证性SNP。这些基因与一些有趣的功能有关，包括“细胞粘附”过程，这些过程有助于建立和维持与成瘾的记忆样特征特别相关的神经元连接。(c) 2006 Wiley-Liss, Inc。
Addictions are substantially heritable complex disorders. We now report whole genome association studies that identify 89 genes likely to contain variants that contribute to addiction vulnerability, using previously- and newly-validated microarray based pooling assays. Each gene contains clustered single nucleotide polymorphisms (SNPs) that display significant allele frequency differences between abusers and controls in each of the two samples studied with 639,401 SNP arrays and confirmatory SNPs from each of two other abuser/control samples. These genes are implicated in interesting functions, including "cell adhesion" processes that help to establish and maintain neuronal connections of special relevance to addiction's memory-like features. (c) 2006 Wiley-Liss, Inc.