The Role of Macrophages in Cancer Development and Therapy.
The Role of Macrophages in Cancer Development and Therapy.
复制标题
巨噬细胞在癌症发展和治疗中的作用。
DOI：
10.3390/cancers13081946
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发表时间：
2021-04-18
期刊：
影响因子：
5.2
通讯作者：
Rygiel TP
中科院分区：
文献类型：
--
作者：
Cendrowicz E;Sas Z;Bremer E;Rygiel TP
肿瘤相关巨噬细胞（Tumor-Associated Macrophages, tam）在肿瘤的发生、新生血管生成、免疫抑制和转移等方面发挥着重要作用。在一些肿瘤类型中，巨噬细胞在肿瘤中的高浸润也与不良预后相关。因此，它们成为癌症免疫治疗的一个有吸引力的靶点。在这篇综述中，我们描述了巨噬细胞在肿瘤发生中的作用，并总结了针对tam的治疗的最新进展。巨噬细胞是组织稳态的重要介质，影响免疫的各个方面。肿瘤相关巨噬细胞是肿瘤微环境的主要细胞成分之一。根据其激活状态，巨噬细胞可以通过拮抗免疫细胞的细胞毒性活性或通过增强抗肿瘤反应（不太常见）对肿瘤发生产生双重影响。在大多数情况下，tam抑制T细胞募集和功能或调节肿瘤免疫的其他方面。tam靶向治疗在癌症治疗中的重要性源于tam在肿瘤组织中的高浸润与患者预后差之间的强烈关联。目前已经开发了几种巨噬细胞靶向抗癌治疗方法，包括TAM耗竭、抑制新的TAM分化或重新教育TAM活化以进行癌细胞吞噬。在这篇综述中，我们将描述tam在肿瘤发展中的作用，包括原瘤性炎症、免疫抑制、新生血管生成、组织侵袭和远处转移增强等方面。此外，我们将讨论旨在消耗tam的治疗方法，或者相反，重新教育tam用于癌细胞吞噬和抗肿瘤免疫。
Tumor-Associated Macrophages (TAMs) play an important role in the development of tumors, modulation of neoangiogenesis, immune suppression, and metastasis. High infiltration of macrophages in the tumor is also correlated with poor prognosis in several cancer types. Therefore, they became an attractive target for cancer immunotherapies. In this review, we describe the role of macrophages in tumorigenesis and summarize the most recent advances in the therapies targeting TAMs. Macrophages are critical mediators of tissue homeostasis and influence various aspects of immunity. Tumor-associated macrophages are one of the main cellular components of the tumor microenvironment. Depending on their activation status, macrophages can exert a dual influence on tumorigenesis by either antagonizing the cytotoxic activity of immune cells or, less frequently, by enhancing antitumor responses. In most situations, TAMs suppress T cell recruitment and function or regulate other aspects of tumor immunity. The importance of TAMs targeting in cancer therapy is derived from the strong association between the high infiltration of TAMs in the tumor tissue with poor patient prognosis. Several macrophage-targeting approaches in anticancer therapy are developed, including TAM depletion, inhibition of new TAM differentiation, or re-education of TAM activation for cancer cell phagocytosis. In this review, we will describe the role of TAMs in tumor development, including such aspects as protumorigenic inflammation, immune suppression, neoangiogenesis, and enhancement of tissue invasion and distant metastasis. Furthermore, we will discuss therapeutic approaches that aim to deplete TAMs or, on the contrary, re-educate TAMs for cancer cell phagocytosis and antitumor immunity.
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影响因子：
3.1
作者：
Brodskyn, CI;DeKrey, GK;Titus, RG
通讯作者：
Titus, RG
影响因子：
4.4
作者：
Buhtoiarov, IN;Lum, H;Rakhmilevich, AL
通讯作者：
Rakhmilevich, AL
影响因子：
10.9
作者：
Cannarile MA;Weisser M;Jacob W;Jegg AM;Ries CH;Rüttinger D
通讯作者：
Rüttinger D
影响因子：
10.9
作者：
Brempelis KJ;Cowan CM;Kreuser SA;Labadie KP;Prieskorn BM;Lieberman NAP;Ene CI;Moyes KW;Chinn H;DeGolier KR;Matsumoto LR;Daniel SK;Yokoyama JK;Davis AD;Hoglund VJ;Smythe KS;Balcaitis SD;Jensen MC;Ellenbogen RG;Campbell JS;Pierce RH;Holland EC;Pillarisetty VG;Crane CA
通讯作者：
Crane CA
影响因子：
5.4
作者：
Brana, Irene;Calles, Antonio;Calvo, Emiliano
通讯作者：
Calvo, Emiliano