Increased levels of interleukin-12 in Plasmodium falciparum malaria:: correlation with the severity of disease
Increased levels of interleukin-12 in Plasmodium falciparum malaria:: correlation with the severity of disease
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DOI：
10.1046/j.1365-3024.2002.00478.x
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发表时间：
2002-07-01
影响因子：
2.2
通讯作者：
Musumeci, S
中科院分区：
文献类型：
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作者：
Malaguarnera, L;Imbesi, RM;Musumeci, S
由单核吞噬细胞产生的白细胞介素（IL）-12激活辅助性T细胞1（Th 1），并作为介体帮助对细胞内微生物的先天性免疫应答。在恶性疟原虫感染中，这种促炎细胞因子具有免疫调节功能，影响对疾病血液阶段的免疫反应，但也诱导保护作用并减少疟疾贫血。在这项研究中，对73名患有严重或轻度恶性疟原虫疟疾的2-144个月（中位数19.5个月）非洲儿童的IL-12水平进行了测定。采用酶联免疫吸附试验测定IL-12。发现IL-12水平在患有较轻疾病的患者中显著升高（21.6 +/-18.3pg/ml）。相比之下，发现患有更严重疾病的患者的IL-12水平较低（13.1 +/- 7.11 pg/ml）。
Interleukin (IL)-12, produced by mononuclear phagocytes, activates the T-helper 1 (Th1) cells and helps, as a mediator, the innate immune response to intracellular microbes. In Plasmodium falciparum infection, this proinflammatory cytokine has immunoregulatory functions with effects on the immune response to the blood stage of disease, but also induces protection and reduces malarial anaemia. In this study, the levels of IL-12 were determined in 73 African children, aged 2-144 months (median 19.5 months), who had severe or mild P. falciparum malaria. IL-12 was determined using the enzyme-linked immunosorbent assay. The levels of IL-12 were found to be significantly elevated (21.6 +/- 18.3 pg/ml) in patients who suffered less severely from the disease. In contrast, the levels of IL-12 were found to be lower (13.1 +/- 7.11 pg/ml) in patients who suffered more severely from the disease.