Net health benefits: A new framework for the analysis of uncertainty in cost-effectiveness analysis
Net health benefits: A new framework for the analysis of uncertainty in cost-effectiveness analysis
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DOI：
10.1177/0272989x98018002s09
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发表时间：
1998-04-01
影响因子：
3.6
通讯作者：
Mullahy, J
中科院分区：
文献类型：
--
作者：
Stinnett, AA;Mullahy, J
近年来，相当多的注意力一直致力于发展的统计方法，用于分析成本效益（CE）分析的不确定性，重点是在这种情况下，分析师有病人水平的数据的成本和健康影响的替代干预措施。迄今为止，讨论几乎完全集中在解决估计CE比率置信区间所涉及的实际挑战上。然而，一般的方法，使用置信区间来传达信息的不确定性CE比率估计遭受理论上的限制，使其在许多情况下是不合适的。作者提出了一种用于分析卫生干预措施经济评估中不确定性的替代框架（“净健康效益”方法），该框架适用范围更广泛，并且避免了先前方法的一些问题。这种方法提供了几个实际和理论上的优势，CE比率的分析，是简单的应用，并强调了CE分析的理论基础的一些重要原则。
In recent years, considerable attention has been devoted to the development of statistical methods for the analysis of uncertainty in cost-effectiveness (CE) analysis, with a focus on situations in which the analyst has patient-level data on the costs and health effects of alternative interventions. To date, discussions have focused almost exclusively on addressing the practical challenges involved in estimating confidence intervals for CE ratios. However, the general approach of using confidence intervals to convey information about uncertainty around CE ratio estimates suffers from theoretical limitations that render it inappropriate in many situations. The authors present an alternative framework for analyzing uncertainty in the economic evaluation of health interventions (the "net health benefits" approach) that is more broadly applicable and that avoids some problems of prior methods. This approach offers several practical and theoretical advantages over the analysis of CE ratios, is straightforward to apply, and highlights some important principles in the theoretical underpinnings of CE analysis.