Prospective validation of the Barcelona Clinic Liver Cancer staging system
Prospective validation of the Barcelona Clinic Liver Cancer staging system
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DOI：
10.1016/j.jhep.2005.12.015
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发表时间：
2006-04-01
影响因子：
25.7
通讯作者：
D'Amico, DF
中科院分区：
文献类型：
--
作者：
Cillo, U;Vitale, A;D'Amico, DF
背景/目标：巴塞罗那临床肝癌（BCLC）分类提供了肝细胞癌（HCC）患者的预后分层。我们最近在一个回顾性的HCC患者队列中证实了BCLC的特殊预后能力。本研究的目的是评估BCLC系统的前瞻性在随后的单独一组的肝癌患者在同一个手术取向liver unit.Methods：一百九十五个连续的肝癌患者前瞻性登记，他们的肝脏疾病分期治疗前。与BCLC治疗方案不同，结节大小和数量不作为根治性治疗的绝对排除标准。结果：BCLC分类A、B、C、D的中位生存时间分别为23个月、53个月、16个月、7个月和3个月。在我们的队列中，BCLC与Okuda、CLIP、UNOS-TNM和JIS预后系统相比，具有最佳的独立生存预测能力（线性趋势卡方（2）=43.01，似然卡方（2）=57.94，AIC 885.98）。此外，BCLC分类表现出更好的预后能力比AJCC-TNM 2002系统在surgical patients.Conclusions：BCLC分期的判别力进行了前瞻性评估，在意大利队列的肝癌患者主要采用根治性治疗。(c)2006年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: The Barcelona Clinic Liver Cancer (BCLC) classification offers a prognostic stratification of patients with hepatocellular carcinoma (HCC). We recently demonstrated the BCLC's peculiar prognostic ability in a retrospective cohort of HCC patients. The aim of this study was to evaluate the BCLC system prospectively in a subsequent separate group of HCC patients enrolled at the same surgically oriented liver unit.Methods: One hundred and ninety-five consecutive HCC patients were prospectively enrolled and their liver disease was staged before therapy. Unlike the BCLC treatment protocol, nodule size and number were not used as absolute exclusion criteria for radical treatment. Predictors of survival were identified using the Cox model.Results: The median survival time was 23 months overall, and 53, 16, 7 and 3 months, respectively, for BCLC categories A, B, C, and D. In our cohort, BCLC had the best independent predictive power for survival when compared with the Okuda, CLIP, UNOS-TNM, and JIS prognostic systems (linear trend chi(2) =43.01, likelihood chi(2) =57.94, AIC 885.98). Moreover, the BCLC classification showed a better prognostic ability than the AJCC-TNM 2002 system in surgical patients.Conclusions: The discriminating power of BCLC staging was prospectively assessed in an Italian cohort of HCC patients treated mainly with radical therapies. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.