T Lymphocyte Numbers and Function in Human IgE‐Mediated Allergy
T Lymphocyte Numbers and Function in Human IgE‐Mediated Allergy
复制标题
人类 IgE 介导的过敏中 T 淋巴细胞的数量和功能
DOI：
10.1111/j.1600-065x.1978.tb01463.x
复制
发表时间：
1978
影响因子：
8.7
通讯作者：
I. Strannegård
中科院分区：
文献类型：
--
作者：
Ö. Strannegård;I. Strannegård
发现反应抗体活性与人类中一种独特的免疫球蛋白 IgE 相关（Ishizaka 等人 1966 年，Johansson 和 Bennich 1967 年），随后很快就在各种动物中证明了 IgE 的存在。这开辟了研究反应素合成调控机制的领域。研究发现，IgE 抗体的产生取决于遗传因素 (Levine & Vaz 1970)、佐剂 (Revoltella & Ovary 1969、StrannegSrd & Chan 1969)、抗原施用途径 (Strannegkrd & Yurchision 1969a) 以及属于其他免疫球类别的抗体 (StrannegSrd & Belin 1970、1971、Tada &奥村 1971 年，石坂和奥平 1972 年）。还发现了关于抗原剂量依赖性的 IgE 产生的特征（Levine & Vaz 1970，StrannegSrd 1973）。人们发现 IgE 合成在几个方面与 IgG 和 IgM 抗体的产生显着不同（Tada 1975）。 Tada (1975) 和 Ishizaka (1976) 总结了 IgE 合成的独特特征。很明显，IgE 合成依赖于 T 细胞和 B 细胞之间的合作（Okumura & Tada 1971，Michael & Bernstein 1973）。 T 辅助细胞和 T 抑制细胞似乎对 IgE 反应产生强烈影响。 Tada 及其同事进行的一系列实验证实了抗原特异性调节性 T 细胞的重要作用（Tada 1975）。多项证据表明抗原非特异性 T 淋巴细胞也调节 IgE 抗体反应。在对兔子反应素反应的研究中，StrannegSrd 和 Yurchision (1969b) 发现，注射半抗原-蛋白缀合物后用 6-巯基嘌呤治疗兔子可显着增强并延长反应素反应的时间。
The discovery that reaginic antibody activity is associated with a unique immunoglobulin class, IgE, in humans (Ishizaka et al. 1966, Johansson & Bennich 1967) was soon followed by demonstrations of IgE also in various animals. This opened the field of studying regulatory mechanisms in reagin synthesis. It was found that the production of IgE antibody is dependent on genetic factors (Levine & Vaz 1970), adjuvants (Revoltella & Ovary 1969, StrannegSrd & Chan 1969), route of antigen administration (Strannegkrd & Yurchision 1969a) and antibodies belonging to other immunoglobuUn classes (StrannegSrd & Belin 1970, 1971, Tada & Okumura 1971, Ishizaka & Okudaira 1972). Characteristic features of IgE production were also found as regards antigen dose dependency (Levine & Vaz 1970, StrannegSrd 1973). In several respects IgE synthesis was found to be markedly different from the production of IgG and IgM antibody (Tada 1975). The distinctive features of IgE synthesis have been summarized by Tada (1975) and Ishizaka (1976). It is evident that IgE synthesis is dependent on cooperation between T and B cells (Okumura & Tada 1971, Michael & Bernstein 1973). T helper cells as well as T suppressor cells appear to exert strong influences on the IgE response. The important role of antigen-specific regulatory T cells has been established in a series of experiments performed by Tada and his associates (Tada 1975). Several lines of evidence suggest that antigen non-specific T lymphocytes also regulate IgE antibody responses. In studies of rabbit reagin response StrannegSrd & Yurchision (1969b) found that treatment of rabbits with 6-mercaptopurin after injection of a hapten-protein conjugate markedly enhanced and prolonged the