The Secrets of Acinetobacter Secretion.
The Secrets of Acinetobacter Secretion.
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DOI：
10.1016/j.tim.2017.01.005
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发表时间：
2017-07
影响因子：
15.9
通讯作者：
Feldman MF
中科院分区：
文献类型：
--
作者：
Weber BS;Kinsella RL;Harding CM;Feldman MF
Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well-defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II and type VI secretion system, autotransporter, and outer membrane vesicles. In this review, we summarize the current knowledge of secretion systems in Acinetobacter species, and highlight their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogens.
