Tumor Microenvironment Responsive Biodegradable Fe-Doped MoOx Nanowires for Magnetic Resonance Imaging Guided Photothermal-Enhanced Chemodynamic Synergistic Antitumor Therapy
Tumor Microenvironment Responsive Biodegradable Fe-Doped MoOx Nanowires for Magnetic Resonance Imaging Guided Photothermal-Enhanced Chemodynamic Synergistic Antitumor Therapy
复制标题
肿瘤微环境响应性可生物降解铁掺杂MoOx纳米线用于磁共振成像引导光热增强化学动力学协同抗肿瘤治疗
DOI：
10.1002/adhm.202001665
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发表时间：
2020-12-16
影响因子：
10
通讯作者：
Hu, Junqing
中科院分区：
文献类型：
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作者：
Chen, Yusheng;Gao, Mengluan;Hu, Junqing
合理设计靶向肿瘤微环境的纳米系统已引起广泛关注。然而，要制造一种多功能的纳米平台，能够主动和选择性地与肿瘤微环境相互作用，而不会对周围的正常组织造成毒性，仍然是一个巨大的挑战。在此，可生物降解的Fe掺杂的MoOx（FMO）纳米线被设计为抗肿瘤纳米试剂，其具有很大的光热转换能力（48.5%）和用于T1加权磁共振成像（MRI）的磁特性。此外，FMO可用作化学动力学治疗（CDT）试剂，以有效催化H2O2分解并产生羟基自由基（中心点OH）。同时，谷胱甘肽的消耗也会增强CDT的效果。更重要的是，FMO呈现pH依赖性降解行为：在生理pH下降解迅速，但在酸性pH下相对稳定。体内抗肿瘤实验表明，FMO能够有效抑制肿瘤生长，且副作用极小。总的来说，这些结果表明FMO在MRI图像引导的癌症治疗中具有巨大的潜力，并促进了纳米药物的临床转化。
Rational design of nanosystems that target tumor microenvironment have attracted widespread attention. However, it is still a great challenge to make a multifunctional nanoplatform that actively and selectively interacts with tumor microenvironment, without causing toxicity to surrounding normal tissues. Herein, the biodegradable Fe-doped MoOx (FMO) nanowires are designed as an anti-tumor nanoreagent that possesses great photothermal conversion ability (48.5%) and magnetic properties for T1 weighted magnetic resonance imaging (MRI). Also, FMO can be used as a chemodynamic therapy (CDT) reagent to effectively catalyze the decomposition of H2O2 and produce hydroxyl radical (center dot OH). At the same time, the consumption of glutathione will also enhance the CDT effect. More importantly, FMO presents pH-dependent degradation behavior: rapid degradation at physiological pH, but relatively stable at acidic pH. In vivo anti-tumor experiment demonstrates that the FMO is able to effectively inhibit the tumor growth with minimal side effects. Generally speaking, these results indicate that the FMO has huge potential for MRI image-guided cancer therapy and promotes the clinical translation of nanodrugs.