Synthesis, characterization and blood compatibility of copolymers derived from polyamidoamines and vinyl acetate
Synthesis, characterization and blood compatibility of copolymers derived from polyamidoamines and vinyl acetate
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DOI：
10.1081/ma-200050470
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发表时间：
2005-03-01
期刊：
影响因子：
--
通讯作者：
Ray, AR
中科院分区：
文献类型：
--
作者：
Dey, RK;Ray, AR
以N，N‘-亚甲基双丙烯酰胺(MBA)和环己胺(CHA)为原料，与醋酸乙烯酯(VAC)共聚，合成了两种不同的聚酰胺胺(PAAS)。用红外光谱、核磁共振氢谱、碳谱等技术对材料进行了表征。接触角测量数据确定了合成的共聚物的相对亲水性。根据血栓形成随时间变化的重量和溶血实验，可以得出结论，为后续材料的体内应用开发提供依据。
This work reports the synthesis of two different polyamidoamines (PAAs), by the reaction of piperazine (Pip) and cyclohexylamine (CHA) with N,N'-methylene bis acrylamide (MBA), which subsequently copolymerized with vinyl acetate (VAC) to improve the mechanical properties of the materials. The materials were characterized by spectroscopic techniques like IR, H-1 NMR, and C-13 NMR. Contact angle measurement data established the relative hydrophilic properties of the synthesized copolymers. From the weight of the thrombus formation with time and hemolysis assay, a conclusion could be drawn for the subsequent development of the materials for in vivo application.