NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction.
NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction.
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DOI：
10.1186/1476-4598-13-40
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发表时间：
2014-02-26
期刊：
影响因子：
37.3
通讯作者：
Cai D
中科院分区：
文献类型：
--
作者：
Ma J;Liu J;Wang Z;Gu X;Fan Y;Zhang W;Xu L;Zhang J;Cai D
促炎细胞因子IL-1β的过度表达与包括癌症在内的多种疾病相关。已经在暴露于促炎细胞因子的癌细胞中观察到microRNA的改变，但它们在炎症应激中的功能仍然是难以捉摸的。在这里，我们表明IL-1β诱导miR-425的上调，miR-425通过靶向其3' UTR负调节磷酸酶和张力蛋白同源物的表达。miR-425的增加依赖于IL-1β诱导的NF-κ B活化，其在IL-1β诱导后增强miR-425基因转录。因此，miR-425对磷酸酶和张力蛋白同源物的抑制促进胃癌细胞增殖，这是保护细胞免受顺铂诱导的凋亡所必需的。综上所述，我们的数据支持NF-κ B依赖性miR-425上调的关键作用，这代表了抑制磷酸酶和张力蛋白同源物活化以及促进IL-1β诱导后细胞存活的新途径。
Overexpression of the proinflammatory cytokine IL-1β is associated with diverse diseases, including cancer. Alteration of microRNAs has been observed in cancer cells exposed to proinflammatory cytokines, yet their function in inflammation stress remains elusive. Here, we show that IL-1β induces the upregulation of miR-425, which negatively regulates phosphatase and tensin homolog expression by targeting its 3’ UTR. An increase in miR-425 depends on IL-1β-induced NF-kappaB activation, which enhances miR-425 gene transcription upon IL-1β induction. Consequently, repression of phosphatase and tensin homolog by miR-425 promotes gastric cancer cell proliferation, which is required to protect cells from cisplatin-induced apoptosis. Taken together, our data support a critical role for NF-kappaB-dependent upregulation of miR-425, which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1β induction.
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影响因子：
4.5
作者：
Di Leva G;Piovan C;Gasparini P;Ngankeu A;Taccioli C;Briskin D;Cheung DG;Bolon B;Anderlucci L;Alder H;Nuovo G;Li M;Iorio MV;Galasso M;Santhanam R;Marcucci G;Perrotti D;Powell KA;Bratasz A;Garofalo M;Nephew KP;Croce CM
通讯作者：
Croce CM
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
12.8
作者：
Lee, Young-Rae;Yu, Hong-Nu;Kim, Jong-Suk
通讯作者：
Kim, Jong-Suk
影响因子：
37.3
作者：
Wu W;Yang J;Feng X;Wang H;Ye S;Yang P;Tan W;Wei G;Zhou Y
通讯作者：
Zhou Y
影响因子：
2.4
作者：
Beales IL
通讯作者：
Beales IL