SOCIAL GLIDING IS CORRELATED WITH THE PRESENCE OF PILI IN MYXOCOCCUS-XANTHUS
SOCIAL GLIDING IS CORRELATED WITH THE PRESENCE OF PILI IN MYXOCOCCUS-XANTHUS
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DOI：
10.1073/pnas.76.11.5952
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
KAISER, D
中科院分区：
文献类型：
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作者：
KAISER, D
M. xanthus 是一种其运动涉及细胞相互作用的生物体，通常具有菌毛。粘球菌菌毛仅存在于细胞极，直径 < 10 nm，可能比细胞还长。粘球菌有两种基本的细胞运动模式：冒险型（A-运动）和社交型（S-运动）。菌毛与 S 运动的存在完全相关。 （S-运动模式有许多细胞群，几乎没有单个细胞是由一组称为系统 S 的基因控制的。）A-运动独立于毛发形成。 （A-运动模式有许多单一的、孤立的细胞，它由称为系统 A 的第二组基因控制。）对 40 多个遗传上不同的菌株进行的 EM 检查表明，所有 A+S+（野生型）和 A-S+ 菌株都有菌毛，但 A+S- 和 A-S- 菌株缺乏菌毛。属于系统 S 的 4 个不同基因座的突变停止了菌毛的产生：基因座 sg1A、sg1B、sg1G 和 tg1。当与 tg1+ 细胞接触时，缺乏菌毛的 tg1- 菌株的细胞会变为表型 S+，产生菌毛并变为 S-能动的。当以这种方式启动时，菌毛的运动和产生都是短暂的。因此，菌毛似乎允许彼此靠近的细胞移动。
M. xanthus, an organism whose motility involves cell interactions, normally bears pili. Myxococcal pili are found only at cell poles, are < 10 nm in diameter and may be longer than a cell. Myxococcus has 2 basic patterns of cell movement, adventurous (A-motility) and social (S-motility). Pili are completely correlated with the presence of S-motility. (The S-motility pattern has many groups of cells, almost no single cells is governed by a set of genes called system S.) A-motility is independent of piliation. (The A-motility pattern has many single, isolated cells and it is governed by a 2nd set of genes called system A.) EM examination of more than 40 genetically different strains shows that all A+S+ (wild-type) and A-S+ strains have pili, but A+S- and A-S- strains lack them. Mutations in 4 different loci belonging to system S stopped production of pili: the loci sg1A, sg1B, sg1G and tg1. When brought into contact with tg1+ cells, cells of a tg1- strain, which lack pili, become phenotypically S+, produce pili, and become S-motile. Both motility and the production of pili are transient when initiated in this way. Thus, it appears that pili permit cells that are close to one another to move.