New developments in RiPP discovery, enzymology and engineering.
New developments in RiPP discovery, enzymology and engineering.
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DOI：
10.1039/d0np00027b
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发表时间：
2021-01-01
影响因子：
11.9
通讯作者：
van der Donk WA
中科院分区：
文献类型：
--
作者：
Montalbán-López M;Scott TA;Ramesh S;Rahman IR;van Heel AJ;Viel JH;Bandarian V;Dittmann E;Genilloud O;Goto Y;Grande Burgos MJ;Hill C;Kim S;Koehnke J;Latham JA;Link AJ;Martínez B;Nair SK;Nicolet Y;Rebuffat S;Sahl HG;Sareen D;Schmidt EW;Schmitt L;Severinov K;Süssmuth RD;Truman AW;Wang H;Weng JK;van Wezel GP;Zhang Q;Zhong J;Piel J;Mitchell DA;Kuipers OP;van der Donk WA
核糖体合成和翻译后修饰肽（RiPPs）是一大类天然产物。2013年，一篇由社区驱动的综述描述了ripp生物合成中出现的共性，以及它们为生物工程和基因组挖掘提供的机会。从那时起，该领域在理解自然界组装这些化合物的机制，设计其广泛应用的生物合成机制以及使用专门为该化合物类开发的生物信息学工具发现全新的RiPP家族方面取得了巨大进展。首届RiPPs国际会议于2019年举行，会议参与者收集了自2013年以来描述新发展的当前综述。本文讨论了已发现的新一类RiPPs，我们对初级和次级翻译后修饰的安装的理解的进展，以及酶识别底物中的先导肽的机制。此外，还讨论了用于发现RiPP的基因组挖掘工具以及RiPP工程的各种策略。展望部分提出了未来研究的方向。本文综述了核糖体合成和翻译后修饰肽（RiPPs）的发现、生物合成和工程方面的最新进展。
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 described the emerging commonalities in the biosynthesis of RiPPs and the opportunities they offered for bioengineering and genome mining. Since then, the field has seen tremendous advances in understanding of the mechanisms by which nature assembles these compounds, in engineering their biosynthetic machinery for a wide range of applications, and in the discovery of entirely new RiPP families using bioinformatic tools developed specifically for this compound class. The First International Conference on RiPPs was held in 2019, and the meeting participants assembled the current review describing new developments since 2013. The review discusses the new classes of RiPPs that have been discovered, the advances in our understanding of the installation of both primary and secondary post-translational modifications, and the mechanisms by which the enzymes recognize the leader peptides in their substrates. In addition, genome mining tools used for RiPP discovery are discussed as well as various strategies for RiPP engineering. An outlook section presents directions for future research. This review provides a comprehensive update of the advances in discovery, biosynthesis, and engineering of ribosomally-synthesized and post-translationally modified peptides (RiPPs).
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DOI：
10.1111/nph.13441
发表时间：
2015-09
期刊：
The New phytologist
影响因子：
--
作者：
Brockington SF;Yang Y;Gandia-Herrero F;Covshoff S;Hibberd JM;Sage RF;Wong GK;Moore MJ;Smith SA
通讯作者：
Smith SA
影响因子：
56.9
作者：
Caputi, Lorenzo;Franke, Jakob;O'Connor, Sarah E.
通讯作者：
O'Connor, Sarah E.
影响因子：
7.4
作者：
Christinet, L;Burdet, FRX;Zryd, JP
通讯作者：
Zryd, JP
影响因子：
1.7
作者：
Amirkia, Vafa;Heinrich, Michael
通讯作者：
Heinrich, Michael
影响因子：
9.4
作者：
Bean, Alexander;Sunnadeniya, Rasika;Lloyd, Alan
通讯作者：
Lloyd, Alan